Background While the detrimental impact of negative emotions on the clinical course of inflammatory bowel disease (IBD) and quality of life has been extensively investigated, evidence for a potential impact of positive emotions is scarce. Objectives We aim to analyse contributing factors of positive affect and their predictive value for disease course in IBD patients. Design In this retrospective cohort study, epidemiological, psychosocial and IBD disease characteristics of Swiss IBD cohort study patients were analysed longitudinally. Methods Epidemiological, psychosocial and disease characteristics were extracted from the database of the Swiss IBD cohort study. Participants' positive emotions were assessed cross-sectionally with the seven-item Marburg questionnaire (range 1-6) addressing positive affect in different aspects of daily life. Predictors of positive emotions were identified by linear regression. The quantitative longitudinal impact of positive emotions on the further disease course was analysed using a multivariable Cox proportional hazards model. Results Among 702 IBD patients, those reporting more positive emotions were found to have significantly less intense medical treatment, less pain and fewer depressive symptoms (p < 0.05). A higher percentage of variability in positive emotions was explained by pain (36%) and depressive symptoms (13%) than by epidemiological characteristics (0.3%), or characteristics of IBD and its treatment (2.4%). Patients with higher levels of positive emotions (score > 3.5) experienced longer flare-free survival, also after adjusting for confounders (adjusted hazard ratio: 0.39, p < 0.05). Conclusions The absence of pain and depressive symptoms were the strongest drivers for high positive affect. Higher scores of positive affect were associated with longer disease-free survival in IBD patients.

中文翻译：

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因为我很高兴 - 炎症性肠病患者的积极影响及其对未来疾病活动的预测价值：一项回顾性队列研究。

背景虽然负面情绪对炎症性肠病（IBD）临床病程和生活质量的有害影响已被广泛研究，但积极情绪潜在影响的证据却很少。目的 我们旨在分析积极影响的影响因素及其对 IBD 患者病程的预测价值。设计 在这项回顾性队列研究中，对瑞士 IBD 队列研究患者的流行病学、心理社会和 IBD 疾病特征进行了纵向分析。方法从瑞士 IBD 队列研究数据库中提取流行病学、心理社会和疾病特征。使用七项马尔堡问卷（范围 1-6）对参与者的积极情绪进行横断面评估，评估日常生活不同方面的积极影响。通过线性回归确定积极情绪的预测因素。使用多变量 Cox 比例风险模型分析积极情绪对进一步病程的定量纵向影响。结果 在 702 名 IBD 患者中，那些报告积极情绪较多的患者的医疗强度明显较低，疼痛和抑郁症状也较少 (p < 0.05)。疼痛 (36%) 和抑郁症状 (13%) 解释积极情绪变异性的比例高于流行病学特征 (0.3%) 或 IBD 及其治疗特征 (2.4%)。积极情绪水平较高（得分 > 3.5）的患者无耀斑生存期较长，调整混杂因素后也是如此（调整后的风险比：0.39，p < 0.05）。结论 没有疼痛和抑郁症状是高积极情感的最强驱动因素。IBD 患者的积极情绪得分越高，无病生存期越长。