The effects of the Eurycoma longifolia (also known as Tongkat Ali [TA]) on sleep and wakefulness was evaluated in C57BL/6 mice. While TA has been used as an aphrodisiac in males, it exhibits various pharmacological effects. The most notable effect observed with TA was wake-enhancement during the second half of the active period, accompanied by significant elevations in core body temperature (CBT). In contrast, sleep was enhanced during the resting period (i.e., increase in rapid eye movement [REM] sleep and delta electroencephalography [EEG] power in non-REM sleep) with significant declines in CBT. The transition of TA's effects between resting and active periods was rapid. The results of the experiments in constant darkness indicate that TA prolongs the circadian tau and that this transition is governed by circadian clock mechanisms rather than light exposure. TA did not demonstrate efficacy in aiding sleep in an acute stress-induced insomnia model; thus, TA may be more suitable as a wake-enhancing agent for daytime sleepiness, as sleep propensity tends to accumulate towards the end of active period. Since TA amplifies the rest-activity pattern, prolongs circadian tau and increases REM sleep, thereby reversing some common symptoms seen in elderly subjects, it may also hold promise as a rejuvenating medicine.

中文翻译：

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东革阿里（Eurycoma longifolia，Tongkat Ali）可增强 C57BL/6 小鼠活动期间的清醒度，并促进休息期间的睡眠

在 C57BL/6 小鼠中评估了东革阿里（Eurycoma longifolia）（也称为东革阿里 [TA]）对睡眠和觉醒的影响。虽然TA已被用作男性的壮阳药，但它表现出多种药理作用。TA 最显着的效果是在活动期的后半段唤醒增强，同时伴随着核心体温 (CBT) 的显着升高。相比之下，休息期间的睡眠得到增强（即快速眼动[REM]睡眠中的快速眼动睡眠和非快速眼动睡眠中的δ脑电图[EEG]功率增加），而CBT显着下降。TA 的作用在休息期和活跃期之间的转变很快。在持续黑暗中的实验结果表明，TA 延长了昼夜节律 tau，并且这种转变是由生物钟机制而不是光照控制的。在急性压力诱发的失眠模型中，TA 并未表现出帮助睡眠的功效；因此，TA 可能更适合作为白天嗜睡的唤醒剂，因为睡眠倾向往往会在活动期结束时积累。由于 TA 可以增强休息-活动模式，延长昼夜节律 tau 并增加快速眼动睡眠，从而逆转老年受试者的一些常见症状，因此它也有望成为一种恢复活力的药物。