Background

Previous adult studies have yielded conflicting results regarding whether the presence (D +) or absence (D-) of peritoneal dialysate affects the accuracy of bioelectrical impedance analysis (BIA) measurements. The aim of this study was to investigate whether the accuracy of BIA data varies between D + and D- measurements in children.

Methods

This cross-sectional study recruited chronic kidney disease stage 5 patients aged 3 to 18 years who received peritoneal dialysis. Body composition was assessed by multifrequency BIA, and values were compared between D + and D- measurements using the intraclass correlation coefficient (ICC).

Results

Fifty paired BIA measurements were collected from 18 patients with a mean age of 13.6 ± 4.1 years and a mean dialysate fill volume of 1,006 ± 239.7 ml/m². Sixteen out of 17 BIA parameters (94.1%) exhibited excellent correlations between D + and D- measurements (ICC values = 0.954, 0.998). There was a trend of increased fluid status, including extracellular water, edema index, and overhydration, in D + measurements, with mean differences (95% CIs) of 0.5 (0.4, 0.6) L, 0.002 (0.001, 0.002), and 0.1 (0.1, 0.2) L, respectively. Soft lean mass and fat-free mass were higher in D + measurements, with mean differences (95% CIs) of 1.4 (1.2, 1.6), and 1.6 (1.4, 1.8) kg, respectively. In addition, patients older than 10 years had a stronger correlation between D + and D- measurements than younger patients.

Conclusions

A total of 94.1% of BIA parameters exhibited excellent correlations between D + and D- measurements, especially patients older than 10 years. We recommend that BIA measurements be collected from children regardless of the presence of peritoneal dialysate.

中文翻译：

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腹膜透析液对接受腹膜透析的儿科患者生物电阻抗分析变异性的影响

背景

先前的成人研究对于腹膜透析液的存在（D +）或不存在（D-）是否影响生物电阻抗分析（BIA）测量的准确性产生了相互矛盾的结果。本研究的目的是调查儿童 D+ 和 D- 测量值之间 BIA 数据的准确性是否存在差异。

方法

这项横断面研究招募了年龄为 3 至 18 岁、接受腹膜透析的慢性肾脏病 5 期患者。通过多频 BIA 评估身体成分，并使用组内相关系数 (ICC) 比较 D + 和 D- 测量值。

结果

从 18 名患者中收集了 50 对 BIA 测量值，平均年龄为 13.6 ± 4.1 岁，平均透析液填充量为 1,006 ± 239.7 ml/m ²。17 个 BIA 参数中的 16 个 (94.1%) 在 D + 和 D- 测量之间表现出极好的相关性（ICC 值 = 0.954、0.998）。D + 测量中存在液体状态增加的趋势，包括细胞外水、水肿指数和过度水合，平均差 (95% CI) 为 0.5 (0.4, 0.6) L、0.002 (0.001, 0.002) 和 0.1分别为（0.1，0.2）L。D+ 测量中的软瘦体重和去脂体重较高，平均差 (95% CI) 分别为 1.4 (1.2, 1.6) 和 1.6 (1.4, 1.8) kg。此外，与年轻患者相比，10 岁以上的患者 D+ 和 D- 测量值之间的相关性更强。

结论

总共 94.1% 的 BIA 参数在 D+ 和 D- 测量之间表现出极好的相关性，尤其是 10 岁以上的患者。我们建议无论是否存在腹膜透析液，都收集儿童的 BIA 测量值。