Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease,Journal of Enzyme inhibition and Medicinal Chemistry

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Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-11-15 , DOI: 10.1080/14756366.2023.2281893
Hongtao Du _{1,

2} , Jinzhi Song ₃ , Fang Ma _{2,

4} , Hongxin Gao ₅ , Xinyan Zhao ₆ , Renjun Mao _{1,

3} , Xiaolong He ₁ , Yan Yan _{1,

2}

Affiliation

In this study, a series of potential ligands for the treatment of AD were synthesised and characterised as novel harmine derivatives modified at position 9 with benzyl piperazinyl. In vitro studies...

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