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Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso.
Journal of the Pediatric Infectious Diseases Society ( IF 3.2 ) Pub Date : 2023-09-27 , DOI: 10.1093/jpids/piad058 Alphonse Ouedraogo 1 , Amidou Diarra 1 , Issa Nébié 1 , Nouhoun Barry 1 , Jean Moise Kabore 1 , Alfred B Tiono 1 , Shrimati Datta 2 , Yuanyuan Liang 2, 3 , Ifayet Mayo 2 , Jennifer J Oshinsky 2 , J Kathleen Tracy 2 , Tsion Girmay 2 , Marcela F Pasetti 2 , Leslie P Jamka 2 , Kathleen M Neuzil 2 , Sodiomon B Sirima 1 , Matthew B Laurens 2
Journal of the Pediatric Infectious Diseases Society ( IF 3.2 ) Pub Date : 2023-09-27 , DOI: 10.1093/jpids/piad058 Alphonse Ouedraogo 1 , Amidou Diarra 1 , Issa Nébié 1 , Nouhoun Barry 1 , Jean Moise Kabore 1 , Alfred B Tiono 1 , Shrimati Datta 2 , Yuanyuan Liang 2, 3 , Ifayet Mayo 2 , Jennifer J Oshinsky 2 , J Kathleen Tracy 2 , Tsion Girmay 2 , Marcela F Pasetti 2 , Leslie P Jamka 2 , Kathleen M Neuzil 2 , Sodiomon B Sirima 1 , Matthew B Laurens 2
Affiliation
We assessed anti-Vi IgG/IgA responses to typhoid conjugate vaccine (TCV) in children enrolled in a double-blind randomized controlled, phase 2 trial in Burkina Faso. Anti-Vi IgG seroconversion and anti-Vi IgA titers were higher in TCV than control recipients at 30-35 months post-vaccination. TCV induces durable immunity in Burkinabe children vaccinated at 15 months.
中文翻译：
布基纳法索接种伤寒结合疫苗的 15 个月大儿童出现持久抗 Vi IgG 和 IgA 抗体反应。
我们评估了布基纳法索参与双盲随机对照 2 期试验的儿童对伤寒结合疫苗 (TCV) 的抗 Vi IgG/IgA 反应。接种后 30-35 个月时，TCV 中的抗 Vi IgG 血清转化和抗 Vi IgA 滴度高于对照接受者。TCV 可在 15 个月大时接种疫苗的布基纳法索儿童中产生持久免疫力。
更新日期：2023-09-27
中文翻译：
布基纳法索接种伤寒结合疫苗的 15 个月大儿童出现持久抗 Vi IgG 和 IgA 抗体反应。
我们评估了布基纳法索参与双盲随机对照 2 期试验的儿童对伤寒结合疫苗 (TCV) 的抗 Vi IgG/IgA 反应。接种后 30-35 个月时，TCV 中的抗 Vi IgG 血清转化和抗 Vi IgA 滴度高于对照接受者。TCV 可在 15 个月大时接种疫苗的布基纳法索儿童中产生持久免疫力。
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