Diabetic wounds impose enormous distress and financial burden on patients, and finding effective dressings to manage wounds is critical. As a Chinese herbal medicine with a long history of Clinical application, Bletilla striata has significant medicinal effects in the therapy of various wounds. In this study, PLA and the pharmacodynamic substances of Bletilla striata were prepared into fibrous scaffolds by emulsion electrospinning technology for the management of diabetic wounds in mice. The results of scanning electron microscopy showed that the core-shell structure fibre was successfully obtained by emulsion electrospinning. The fibre membrane exhibited excellent water absorption capability and water vapor transmission rate, could inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa, had good compatibility, and achieved excellent healing effect on diabetic wounds. Especially in the in vivo wound healing experiment, the wound healing rate of composite fibre membrane treatment reached 98.587 ± 2.149% in 16 days. This work demonstrated the good therapeutic effect of the developed fibrous membrane to diabetic wound, and this membrane could be potentially applied to chronic wound healing.

中文翻译：

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通过乳液静电纺丝制备白芨复合纳米纤维膜，用于增强糖尿病伤口的愈合。

糖尿病伤口给患者带来巨大的痛苦和经济负担，找到有效的敷料来处理伤口至关重要。白及作为临床应用历史悠久的中草药，在治疗各种创伤方面具有显着的药用效果。本研究采用乳液静电纺丝技术将PLA和白及药效物质制备成纤维支架，用于治疗小鼠糖尿病伤口。扫描电镜结果表明，通过乳液静电纺丝成功获得了核壳结构纤维。该纤维膜表现出优异的吸水能力和水蒸气透过率，能够抑制金黄色葡萄球菌和铜绿假单胞菌的生长，具有良好的相容性，对糖尿病伤口具有良好的愈合效果。特别是在体内伤口愈合实验中，复合纤维膜治疗的伤口愈合率在16天内达到98.587±2.149%。这项工作证明了所开发的纤维膜对糖尿病伤口的良好治疗效果，并且该膜有可能应用于慢性伤口愈合。