Objective

The main aim of this research was to evaluate the effect of mixed herbs on blood HbA1c, and the liver function tests in type 2 diabetes mellitus (T2DM) patients.

Methods

This was a quasi-experimental design where no comparison was made with either placebo or control. We examined the effect of herbs namely, coriander leaves (Coriandrum sativum), bunching onion (Allium fistulosum), curry leaves (Murraya koenigii), and holy basil leave (Ocimum tenuiflorum) among T2DM patients. Fresh herbs were cleaned, freeze-dried, ground, mixed (25 % of each), encapsulated and fed at 4 g/day to T2DM patients for 90 days. Blood samples were collected on days 0, 31, 61, 91 and 121. The effect was assessed on the levels of HbA1c, creatinine, blood urea and liver enzymes i.e., alanine transaminase (ALT) or serum glutamic-pyruvic transaminase (SGPT), aspartate aminotransferase (AST) or serum glutamic-oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), among the patients. The data were statistically analysed, and the means were regarded as significant at 95 % CI. interval.

Results

Blood HbA1c concentration was highest on Days 0 and 31 and significantly (p < 0.001 and p < 0.01) reduced on Days 61, 91 and 121. The creatinine and urea concentrations were found to increase but not considerable with larger variation among the subjects. The ALT and AST concentrations were found higher (p < 0.001) on Day 60 but started to decline afterwards. The ALP levels were higher on the Days 0 and 31 but started declining from Day 61 onwards.

Conclusion

The consumption of mixed herbs was found to be associated with an improvement of HbA1c level among T2DM patients without having any clinically significant change in blood urea, creatinine, and liver enzymes.

中文翻译：

---

多药制剂对 2 型糖尿病患者的抗糖尿病活性评价

客观的

本研究的主要目的是评估混合草药对 2 型糖尿病 (T2DM) 患者血液 HbA1c 和肝功能测试的影响。

方法

这是一个准实验设计，没有与安慰剂或对照组进行比较。我们研究了草药，即芫荽叶 ( Coriandrum sativum )、葱 ( Allium fistulosum )、咖喱叶 (Murraya koenigii) 和圣罗勒叶 ( Ocimum tenuiflorum ) 对 T2DM 患者的作用。新鲜草药经过清洗、冷冻干燥、研磨、混合（每种 25%）、封装并以 4 克/天的剂量喂给 T2DM 患者，持续 90 天。在第 0、31、61、91 和 121 天采集血样。评估 HbA1c、肌酐、血尿素和肝酶（即丙氨酸转氨酶 (ALT) 或血清谷氨酸-丙酮酸转氨酶 (SGPT)）水平的影响，患者中天冬氨酸转氨酶（AST）或血清谷氨酸草酰乙酸转氨酶（SGOT）、碱性磷酸酶（ALP）。对数据进行统计分析，平均值在 95% CI 下被视为显着。间隔。

结果

血液 HbA1c 浓度在第 0 天和第 31 天最高，并在第 61 天、第 91 天和第 121 天显着降低（p < 0.001 和 p < 0.01）。肌酐和尿素浓度被发现增加，但不显着，受试者之间差异较大。第 60 天，ALT 和 AST 浓度较高（p < 0.001），但随后开始下降。ALP 水平在第 0 天和第 31 天较高，但从第 61 天开始下降。

结论

研究发现，服用混合草药与 T2DM 患者的 HbA1c 水平改善相关，而血尿素、肌酐和肝酶没有任何临床显着变化。