Because of the stigma surrounding patients with substance use disorder (SUD) and difficulties with follow-up, data on outcomes is limited. We explore real-world data from a prospectively collected database to determine characteristics that contribute to the completion of acute treatment. Our cohort consisted of data from 1039 patients treated at a single facility. Success was defined as successful discharge from the program. Failure was defined as relapse or signing out against medical advice during treatment. We examined 43 distinct features collected at time of treatment using multivariate analysis. In the total cohort and both sexes, longer length of stay (p ≤ 0.01) was linked to treatment failure. When we examined the cohort by sex, variables associated with success and failure differed between groups. Among females, goal-directed thinking (p ≤ 0.05) correlated with treatment success. Taking unnecessary risks (p < 0.05), having a detailed suicide plan (p ≤ 0.001), and constricted thinking (p ≤ 0.01) predicted treatment failure. In males, prior arrest for driving under the influence (p ≤ 0.05), and presence of phobias, paranoias, and delusions (p ≤ 0.05) were associated with treatment failure. Identifying patients prone to acute therapy failure may guide more personalized treatment, thereby increasing success rates. When considering SUD treatments for patients, we must stratify based on patient characteristics.

中文翻译：

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影响药物滥用障碍治疗短期成功的变量的性别差异。

由于物质使用障碍 (SUD) 患者的耻辱感和随访困难，有关结果的数据有限。我们从前瞻性收集的数据库中探索真实世界的数据，以确定有助于完成急性治疗的特征。我们的队列由在单一机构接受治疗的 1039 名患者的数据组成。成功被定义为成功退出该计划。失败被定义为治疗期间复发或不遵守医疗建议。我们使用多变量分析检查了治疗时收集的 43 个不同特征。在整个队列和男女中，较长的住院时间（p≤0.01）与治疗失败相关。当我们按性别检查队列时，与成功和失败相关的变量在组之间有所不同。在女性中，目标导向思维 (p ≤ 0.05) 与治疗成功相关。承担不必要的风险（p < 0.05）、制定详细的自杀计划（p ≤ 0.001）和狭隘思维（p ≤ 0.01）可预测治疗失败。在男性中，先前因酒后驾车被捕（p≤0.05）以及存在恐惧症、偏执狂和妄想症（p≤0.05）与治疗失败相关。识别容易出现急性治疗失败的患者可能会指导更个性化的治疗，从而提高成功率。在考虑对患者进行 SUD 治疗时，我们必须根据患者特征进行分层。