BACKGROUND Coronary slow flow (CSF) is a condition characterized by impaired blood flow rates in the coronary arteries. It can result in severe cardiovascular outcomes. There is not sufficient evidence regarding the certain etiology and reversibility of slow flow patterns and change in frame counts with long-term management. METHODS We retrospectively enrolled 48 patients with chronic coronary syndrome and CSF who underwent a second angiography. A corrected coronary frame rate (CFR) > 27 was defined as CSF. We created 3 groups according to the change in CSF status as the improved, not changed, and worsened groups. We compared the CFR and CSF status of the patients between the first and second angiographies within a median of 2.6 years. RESULTS We determined a non-significant change in cCFR in LAD (34.4 [18.9] vs. 31.59 [10.3], p=0.35), Cx (42.84 [12.56] vs. 40.66 [13.2], p=0.35), and RCA arteries (57.80 [30.13] vs. 50.32 [19.5], p=0.11). In the comparison of CSF status of LAD (75% vs. 63%, p=0.27), Cx (96% vs. 83%, p=0.09), RCA (94% vs. 94%, p=1.0) between first and second angiographies there was no significant change. In the comparison of 3 the groups according to the improvement of CSF status, there was not any significant difference in demographic features, change in laboratory parameters, and time between the groups. CONCLUSION In conclusion, there was no significant change in the median CFR and CSF status in the overall group between the two angiographies after 3 years.

中文翻译：

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冠状动脉慢血流患者血流量的长期变化。

背景技术冠状动脉慢血流(CSF)是一种以冠状动脉血流速度受损为特征的病症。它可能导致严重的心血管后果。没有足够的证据证明慢流模式的某些病因和可逆性以及长期管理引起的帧数变化。方法 我们回顾性纳入 48 名患有慢性冠状动脉综合征和脑脊液的患者，并接受了第二次血管造影。校正冠状动脉帧率 (CFR) > 27 定义为 CSF。我们根据CSF状态的变化创建了3组：改善组、未改变组和恶化组。我们比较了中位 2.6 年内第一次和第二次血管造影患者的 CFR 和 CSF 状态。结果 我们确定 LAD（34.4 [18.9] vs. 31.59 [10.3]，p=0.35）、Cx（42.84 [12.56] vs. 40.66 [13.2]，p=0.35）和 RCA 动脉的 cCFR 无显着变化（57.80 [30.13] 与 50.32 [19.5]，p=0.11）。在第一组之间 LAD（75% vs. 63%，p=0.27）、Cx（96% vs. 83%，p=0.09）、RCA（94% vs. 94%，p=1.0）的 CSF 状态比较中第二次血管造影没有明显变化。根据脑脊液状态的改善情况对3个组进行比较，组间人口统计学特征、实验室参数变化和时间没有任何显着差异。结论 总之，3 年后两次血管造影之间，整个组的中位 CFR 和 CSF 状态没有显着变化。