AIM To investigate the possible covariation of grey matter volume (GMV) and white matter fractional anisotropy in infants with spastic cerebral palsy (CP) and periventricular white matter injury. METHOD Thirty-nine infants with spastic CP and 25 typically developing controls underwent structural magnetic resonance imaging and diffusion tensor imaging. Multimodal canonical correlation analysis with joint independent component analysis were used to capture differences in GMV and fractional anisotropy between groups. Correlation analysis was performed between imaging findings and clinical features. RESULTS Infants with spastic CP showed one joint group-discriminating component (i.e. GMV-fractional anisotropy) associated with regions in the cortico-basal ganglia-thalamo-cortical loop and in the corpus callosum compared to typically developing controls and one modality-specific group-discriminating component (i.e. GMV). Significant negative correlations were found between loadings in certain regions and the motor function score in spastic CP. INTERPRETATION In infants with spastic CP, covarying GMV-fractional anisotropy and altered GMV in specific regions were implicated in motor dysfunction, which confirmed that simultaneous GMV and fractional anisotropy changes underly motor deficits, but might also extend to sensory, cognitive, or visual dysfunction. These findings also suggest that multimodal fusion analysis allows for a more comprehensive understanding of the relevance between grey and white matter structures and its crucial role in the neuropathological mechanisms of spastic CP.

中文翻译：

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痉挛性脑瘫合并脑室周围白质损伤婴儿脑灰质和白质的结构。

目的探讨痉挛性脑瘫（CP）合并脑室周围白质损伤婴儿灰质体积（GMV）和白质各向异性分数可能的协变。方法 对 39 名患有痉挛性脑瘫的婴儿和 25 名正常发育的对照婴儿进行了结构磁共振成像和弥散张量成像。使用多模态典型相关分析和联合独立成分分析来捕获组间 GMV 和分数各向异性的差异。对影像学表现与临床特征之间进行相关性分析。结果 与典型发育对照和一种特定模式组相比，患有痉挛性脑瘫的婴儿表现出一种与皮质基底节-丘脑-皮质环和胼胝体区域相关的关节组区分成分（即 GMV 分数各向异性）。区分成分（即 GMV）。在痉挛性脑瘫中，某些区域的负荷与运动功能评分之间存在显着的负相关。解释 在患有痉挛性脑瘫的婴儿中，共变的 GMV 分数各向异性和特定区域的 GMV 改变与运动功能障碍有关，这证实了同时的 GMV 和分数各向异性变化是运动缺陷的基础，但也可能扩展到感觉、认知或视觉功能障碍。这些发现还表明，多模态融合分析可以更全面地了解灰质和白质结构之间的相关性及其在痉挛性脑瘫神经病理机制中的关键作用。