Background Heart rate (HR) changes associated with seizures are promising biomarkers in epilepsy. Aims The aim of our study is to reveal possible HR changes in the peri-ictal period. Methods Long-term video-EEG monitorization records of generalized and focal epilepsy patients were reviewed. HRs were calculated in the pre-ictal (2 min before the first seizure activity in EEG), ictal (the time from the first seizure activity on the EEG to the end of the seizure), and in the interictal period (at least 2 h before or 12 h after the seizure). Interictal, pre-ictal, and ictal HRs were compared with each other. In addition, it was investigated whether peri-ictal HR changes differ between generalized and focal seizure patients. Results Focal motor seizures were observed in 21, and generalized tonic-clonic seizures were observed in 18 of 39 (22 female and 17 male) patients studied. HRs in the pre-ictal and ictal periods were significantly higher than in the interictal period. This significant increase in HR was validated separately in both focal and generalized seizure groups and was not different between the two groups. Conclusion Our study supports previous studies showing the presence of increased peri-ictal HR and also provides new insights by comparing focal and generalized motor seizures. We think that our findings may contribute to the development of early warning signs in epilepsy patients.

中文翻译：

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癫痫患者的围发作期心率变化。

背景 与癫痫发作相关的心率（HR）变化是癫痫有希望的生物标志物。目的 我们研究的目的是揭示围发作期可能发生的心率变化。方法回顾全身性和局灶性癫痫患者的长期视频脑电图监测记录。计算发作前（EEG 中第一次癫痫发作活动前 2 分钟）、发作期（EEG 中第一次癫痫发作到癫痫发作结束的时间）和发作间期（至少 2 小时）的 HR。癫痫发作前或癫痫发作后 12 小时）。比较发作间期、发作前和发作期的 HR。此外，还调查了全身性癫痫发作和局灶性癫痫发作患者的围发作期 HR 变化是否不同。结果 在 39 名患者（22 名女性和 17 名男性）中，21 名患者观察到局灶性运动性癫痫发作，18 名患者观察到全身强直阵挛性癫痫发作。发作前和发作期的 HR 显着高于发作间期。HR 的显着增加在局灶性癫痫发作组和全身性癫痫发作组中分别得到验证，并且两组之间没有差异。结论 我们的研究支持了之前的研究，表明发作期 HR 增加，并且通过比较局灶性和全身性运动性癫痫发作提供了新的见解。我们认为我们的发现可能有助于癫痫患者早期预警信号的出现。