Background/Aims The recent update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added normal growth in children as an intermediate target in Crohn's disease and ulcerative colitis. We aimed to investigate factors associated with reaching mid-parental height (MPH) in patients diagnosed with inflammatory bowel disease in childhood and the adolescent period. Methods This multicenter retrospective observational study included pediatric patients with inflammatory bowel disease that had reached adult height. Factors associated with reaching MPH were investigated by logistic regression analyses. Results A total of 166 patients were included in this study (128 Crohn's disease and 38 ulcerative colitis). Among them, 54.2% (90/166) had reached their MPH. Multivariable logistic regression analysis revealed that height Z-score at diagnosis and MPH Z-score were independently associated with reaching MPH (odds ratio [OR], 8.45; 95% confidence interval [CI], 4.44 to 17.90; p<0.001 and OR, 0.11; 95% CI, 0.04 to 0.24; p<0.001, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level of "height Z-score at diagnosis minus MPH Z-score" that was associated with reaching MPH was -0.01 with an area under the curve of 0.889 (95% CI [0.835 to 0.944], sensitivity 88.9%, specificity 84.2%, positive predictive value 87.0%, negative predictive value 86.5%, p<0.001). Conclusions Height Z-score at diagnosis and MPH Z-score were the only factors associated with reaching MPH. Efforts should be made to restore growth in pediatric patients who present with a negative "height Z-score at diagnosis minus MPH Z-score."

中文翻译：

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儿童和青少年时期被诊断患有炎症性肠病的患者达到父母中等身高的相关因素。

背景/目标 最近关于选择炎症性肠病治疗目标计划的更新将儿童的正常生长作为克罗恩病和溃疡性结肠炎的中间目标。我们的目的是调查儿童和青少年时期被诊断患有炎症性肠病的患者达到父母中期身高 (MPH) 的相关因素。方法 这项多中心回顾性观察研究纳入了已达到成人身高的炎症性肠病儿科患者。通过逻辑回归分析研究了与达到 MPH 相关的因素。结果 本研究共纳入 166 例患者（克罗恩病 128 例，溃疡性结肠炎 38 例）。其中，54.2% (90/166) 已达到 MPH。多变量逻辑回归分析显示，诊断时身高 Z 得分和 MPH Z 得分与达到 MPH 独立相关（优势比 [OR]，8.45；95% 置信区间 [CI]，4.44 至 17.90；p<0.001 且 OR， 0.11；95% CI，0.04 至 0.24；p<0.001，分别）。根据受试者工作特征曲线分析，与达到 MPH 相关的“诊断时身高 Z 得分减去 MPH Z 得分”的最佳截止水平为 -0.01，曲线下面积为 0.889（95% CI [0.835]至 0.944]，敏感性 88.9%，特异性 84.2%，阳性预测值 87.0%，阴性预测值 86.5%，p<0.001）。结论 诊断时身高 Z 得分和 MPH Z 得分是与达到 MPH 相关的唯一因素。应努力恢复“诊断时身高 Z 得分减去 MPH Z 得分”为负值的儿科患者的生长。