BACKGROUND Limited data exist about the vaccination of children with idiopathic thrombocytopenic purpura (ITP) against vaccine preventable diseases. This study identified the vaccination status of children with ITP against hepatitis A, hepatitis B, measles, mumps, rubella and varicella, completed the immunization of children with inadequate immunization, re-evaluated post-vaccination antibody titers and identified probable vaccination-related complications. PATIENTS AND METHODS All of 46 children had chronic ITP were included. Seroconversion of hepatitis A, hepatitis B, varicella, measles, rubella and mumps vaccines was screened. All children with seronegative antibodies against vaccine preventable disease were given a vaccination appointment. Antibody levels were re-measured during a period ranging from 1 to 6 months. Potential complications were detected. RESULTS There were 46 children with a mean age of 12.25 years. All children had chronic ITP and received intravenous immunoglobulin at least once previously. Considering the vaccination status, 50% (23 children) had vaccinations appropriate for their age, 47.8% (22 children) did not know their vaccination status and 2.2% (1 patient) did not have vaccinations. Seven children (15.2%) were seropositive for all antibody types and the remaining 39 children were scheduled for vaccination. Post-vaccination antibody titers confirmed that all children became seropositive for each disease. There was no complication in any patient. CONCLUSION Immunization against hepatitis B, hepatitis A, measles, mumps, rubella and varicella is insufficient in a considerable number of children with ITP, Hepatitis B Virus (HBV) and Hepatitis A Virus (HAV) immunization being the most frequently inadequate. After immunization, adequate seroconversion levels were achievable without complications.

中文翻译：

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特发性血小板减少性紫癜儿童乙型肝炎、甲型肝炎、麻疹、流行性腮腺炎、风疹、水痘的补种和强化免疫。

背景 关于患有特发性血小板减少性紫癜（ITP）的儿童针对疫苗可预防疾病进行疫苗接种的数据有限。本研究明确了ITP儿童甲型肝炎、乙型肝炎、麻疹、流行性腮腺炎、风疹和水痘的疫苗接种状况，完成了免疫不足儿童的免疫接种，重新评估了疫苗接种后抗体滴度，并识别了可能的疫苗相关并发症。患者和方法 所有 46 名患有慢性 ITP 的儿童都被纳入其中。对甲型肝炎、乙型肝炎、水痘、麻疹、风疹和流行性腮腺炎疫苗的血清转化进行了筛查。所有具有针对疫苗可预防疾病的血清阴性抗体的儿童都接受了疫苗接种预约。在 1 至 6 个月的时间内重新测量抗体水平。检测到潜在的并发症。结果 儿童46名，平均年龄12.25岁。所有儿童均患有慢性 ITP，并且之前至少接受过一次静脉注射免疫球蛋白。从疫苗接种情况来看，50%（23名儿童）接种了适合其年龄的疫苗，47.8%（22名儿童）不知道自己的疫苗接种情况，2.2%（1名患者）没有接种疫苗。7 名儿童 (15.2%) 所有抗体类型均呈血清阳性，其余 39 名儿童计划接种疫苗。疫苗接种后抗体滴度证实所有儿童的每种疾病均呈血清阳性。所有患者均未出现并发症。结论相当数量的ITP儿童乙型肝炎、甲型肝炎、麻疹、流行性腮腺炎、风疹和水痘免疫接种不足，其中乙型肝炎病毒(HBV)和甲型肝炎病毒(HAV)免疫接种不足最为常见。免疫接种后，可以达到足够的血清转化水平，且没有并发症。