Background Dietary therapy may potentially reduce inflammation and promote mucosal healing in patients with Crohn's disease and is associated with fewer side effects and lower cost compared to medical therapy. Recently the Crohn's disease exclusion diet (CDED) has been developed to reduce exposure to individualized dietary components which negatively affect the intestine in patients with Crohn's disease. Objectives This systematic review aimed to explore the effectiveness of CDED in Crohn's disease patients. Design A systematic review. Data sources and methods A systematic search was performed on the PubMed, EBSCOhost, Cochrane library, OVID, Embase, Scopus, and CINHAL to identify relevant clinical trials published from 1 January 2014 to 31 August 2022. Results A total of 1120 studies were identified and 7 studies were finally included in the analysis. The study was reported according to Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Conclusion Our findings suggested that the use of CDED seemed to be effective for induction and maintenance of remission in children and adults with mild to moderate Crohn's disease. However, heterogeneity and limitations existed among the studies included. Further investigation in the form of well-designed randomized clinical trials is needed to validate the present findings. Registration PROSPERO registration number CRD42022335453.

中文翻译：

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克罗恩病排除饮食对缓解的影响：系统评价。

背景饮食疗法可能会减少克罗恩病患者的炎症并促进粘膜愈合，并且与药物治疗相比副作用更少，成本更低。最近，克罗恩病排除饮食（CDED）被开发出来，以减少克罗恩病患者接触对肠道产生负面影响的个性化饮食成分。目的 本系统评价旨在探讨 CDED 对克罗恩病患者的有效性。设计 系统回顾。数据来源和方法 在 PubMed、EBSCOhost、Cochrane 图书馆、OVID、Embase、Scopus 和 CINHAL 上进行系统检索，以识别 2014 年 1 月 1 日至 2022 年 8 月 31 日发表的相关临床试验。 结果 共识别出 1120 项研究，最终纳入7项研究进行分析。该研究是根据系统评价和荟萃分析声明的首选报告项目进行报告的。结论 我们的研究结果表明，使用 CDED 似乎可以有效诱导和维持患有轻度至中度克罗恩病的儿童和成人的缓解。然而，纳入的研究之间存在异质性和局限性。需要以精心设计的随机临床试验的形式进行进一步研究来验证目前的发现。注册 PROSPERO 注册号 CRD42022335453。