INTRODUCTION This study evaluated the correlation between skin blood flow and systemic blood flow and whether skin blood flow can determine the circulatory effects of dopamine and dobutamine on blood flow in very low birth weight (VLBW) infants. METHODS This study was a subanalysis of the PICC-MBF randomized controlled trial. The correlation between skin blood flow and echocardiographic findings was examined. Changes in skin blood flow and blood pressure before and after initiation or dose increase of dopamine and dobutamine were also evaluated. RESULTS Two hundred and thirty-four participants underwent echocardiography. Skin blood flow was significantly correlated with supra vena cava (SVC) flow (r = 0.31, p < 0.001). Receiver operator characteristic analysis revealed that skin blood flow <17 mL/min effectively detected SVC flow <41 mL/min (area under the curve = 0.83, p < 0.001). Dobutamine significantly increased skin blood flow after initiation or dose increase (p = 0.033) without increasing blood pressure. However, dopamine significantly increased both skin blood flow (p = 0.010) and blood pressure (p < 0.001). CONCLUSIONS Our findings indicated that skin blood flow could be used as a surrogate marker of systemic blood flow in VLBW infants and revealed differences in the effects of dopamine and dobutamine on circulation.

中文翻译：

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儿茶酚胺对早产儿血流的影响：PICC-MBF 试验的亚组分析。

引言本研究评估了皮肤血流量与全身血流量之间的相关性，以及皮肤血流量是否可以确定多巴胺和多巴酚丁胺对极低出生体重（VLBW）婴儿血流量的循环影响。方法 本研究是 PICC-MBF 随机对照试验的亚分析。检查皮肤血流量和超声心动图结果之间的相关性。还评估了多巴胺和多巴酚丁胺开始或剂量增加之前和之后皮肤血流量和血压的变化。结果 234 名参与者接受了超声心动图检查。皮肤血流量与上腔静脉（SVC）流量显着相关（r = 0.31，p < 0.001）。接收者操作员特征分析显示，皮肤血流量 <17 mL/min 可以有效检测到 SVC 流量 <41 mL/min（曲线下面积 = 0.83，p < 0.001）。多巴酚丁胺在开始使用或增加剂量后显着增加皮肤血流量（p = 0.033），而不会增加血压。然而，多巴胺显着增加皮肤血流量（p = 0.010）和血压（p < 0.001）。结论 我们的研究结果表明，皮肤血流量可作为极低出生体重婴儿全身血流量的替代指标，并揭示多巴胺和多巴酚丁胺对循环影响的差异。