New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity,Journal of Enzyme inhibition and Medicinal Chemistry

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New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-11-15 , DOI: 10.1080/14756366.2023.2281263
Daopeng Tan _{1,

2} , Jianmei Wang ₁ , Xianting Wang ₁ , Lin Qin _{1,

2} , Yimei Du _{1,

2} , Changkuo Zhao ₁ , Peijun Liu ₁ , Qianru Zhang _{1,

2} , Feifei Ma _{1,

2} , Jian Xie _{1,

2} , Di Wu _{1,

2} , Yuqi He _{1,

2}

Affiliation

Protein tyrosine phosphatase 1B (PTP1B) is a key factor and regulator of glucose, lipid metabolism throughout the body, and a promising target for treatment of type 2 diabetes mellitus (T2DM). Gyno...

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