Macrophage colony-stimulating factor (CSF1) controls the proliferation and differentiation of cells of the mononuclear phagocyte system through binding to the receptor CSF1R. The expression and function of CSF1 has been well-studied in rodents and humans, but knowledge is lacking in other veterinary species. The development of a novel mouse anti-porcine CSF1 monoclonal antibody (mAb) facilitates the characterisation of this growth factor in pigs. Cell surface expression of CSF1 was confirmed on differentiated macrophage populations derived from blood and bone marrow monocytes, and on lung resident macrophages, the first species for this to be confirmed. However, monocytes isolated from blood and bone marrow lacked CSF1 expression. This species-specific mAb delivers the opportunity to further understanding of porcine myeloid cell biology. This is not only vital for the role of pigs as a model for human health, but also as a veterinary species of significant economic and agricultural importance.

巨噬细胞集落刺激因子 (CSF1) 通过与受体 CSF1R 结合来控制单核吞噬细胞系统细胞的增殖和分化。CSF1 的表达和功能已在啮齿动物和人类中得到充分研究，但在其他兽医物种中缺乏相关知识。新型小鼠抗猪 CSF1 单克隆抗体 (mAb) 的开发促进了这种生长因子在猪体内的表征。CSF1 的细胞表面表达在源自血液和骨髓单核细胞的分化巨噬细胞群以及肺驻留巨噬细胞上得到证实，这是第一个得到证实的物种。然而，从血液和骨髓中分离的单核细胞缺乏 CSF1 表达。这种物种特异性单克隆抗体为进一步了解猪骨髓细胞生物学提供了机会。这不仅对于猪作为人类健康模型的作用至关重要，而且作为具有重要经济和农业重要性的兽医物种。