Oxide nanoparticles (NPs) have attracted considerable interest owing to their unique characteristics and possible applications, including gas detection, bioanalytical sensing, catalytic, and biomedical. The present work was designed to explore the effect of varying amounts (2.5%, 5%, and 7.5 mol%) of Zn-doping on the properties and selective anticancer efficacy of In₂O₃ NPs. The precipitation process was applied to prepare pure In₂O₃ NPs and Zn-doped In₂O₃ NPs. XRD, TEM, SEM, EDX, XPS, UV-Vis, and PL techniques have been employed to investigate the physicochemical properties of NPs. The XRD analysis revealed that the crystallite of the In₂O₃ lattice was slightly changed with the addition of Zn ions. TEM and SEM images displayed that the reduction of size of In₂O₃ NPs was increased with increasing Zn concentrations. The composition elements and distribution of Zn dopants within In₂O₃ NPs were further confirmed by EDX and XPS techniques. Based on the UV-Vis study, increasing the Zn amount improved the gap energy of In₂O₃ NPs by shifting edge absorption peaks to lower wavelengths. Moreover, PL spectra show that the intensity of In₂O₃ NPs decreased with increasing the Zn amount. The biological results indicate that the Zn-doped In₂O₃ NPs exhibited a significant increase in cytotoxicity with Zn doping increased against MCF-7 HCT116) cells while they have excellent biocompatibility with normal human cells (HUVECs). These results suggest that these NPs hold promise as a novel therapeutic approach in cancer treatment. This study requires more research into the biological applications of Zn-doped In₂O₃ NPs.

氧化物纳米粒子（NP）由于其独特的特性和可能的​​应用（包括气体检测、生物分析传感、催化和生物医学）而引起了人们极大的兴趣。本工作旨在探讨不同量（2.5%、5%和7.5 mol%）的Zn掺杂对In 2 O 3 NPs的性质和选择性抗癌_功效的_影响。采用沉淀法制备了纯In ₂ O ₃纳米粒子和Zn掺杂的In ₂ O ₃纳米粒子。XRD、TEM、SEM、EDX、XPS、UV-Vis 和 PL 技术已用于研究 NP 的物理化学性质。XRD分析表明，随着Zn离子的添加​​， In ₂ O _{3晶格的微晶发生了轻微的变化。TEM和SEM图像显示In 2} O ₃ NPs的尺寸减小随着Zn浓度的增加而增加。通过EDX和XPS技术进一步证实了In ₂ O ₃ NPs中Zn掺杂剂的组成元素和分布。根据紫外-可见光研究，增加 Zn 含量可通过将边缘吸收峰移至较低波长来提高 In ₂ O _{3 NP 的带隙能量。此外，PL光谱显示In 2} O ₃ NPs的强度随着Zn含量的增加而降低。生物学结果表明，随着Zn掺杂的增加，Zn掺杂的In ₂ O ₃ NPs对MCF-7 HCT116)细胞的细胞毒性显着增加，同时与正常人细胞(HUVEC)具有优异的生物相容性。这些结果表明这些纳米颗粒有望成为癌症治疗的一种新型治疗方法。这项研究需要对Zn掺杂In ₂ O ₃ NPs的生物学应用进行更多研究。