INTRODUCTION The concept of allostatic load encompasses the cumulative effects of both ordinary daily life events as well as major challenges, and also includes related health-damaging behavior. Allostatic overload ensues when environmental challenges exceed the individual's ability to cope. Identification of allostatic load is carried out through the use of biomarkers and clinimetric criteria. Studies are increasingly reported on allostatic load in younger populations, yet a systematic review is missing. OBJECTIVE The aim of the present systematic review was to summarize the current knowledge on allostatic load/overload among children and adolescents. METHODS PubMed, PsycINFO, Web of Science, and the Cochrane Library were searched from inception to April 2023. A manual search of the literature was also performed. We considered only studies in which allostatic load or overload were adequately described and assessed in either clinical or non-clinical populations younger than 18 years. RESULTS A total of 38 original investigations were included in this systematic review. Studies reported an association between allostatic load and sociodemographic characteristics (e.g., poverty, ethnicity, perceived discrimination, adverse childhood experiences) and environmental factors, as well as consequences of allostatic load on both physical and mental health among children and adolescents. CONCLUSIONS The findings indicate that greater allostatic load is associated with poorer health outcomes in both clinical and non-clinical pediatric populations, with possible enduring effects. The results support the clinical utility of the transdiagnostic identification of allostatic load and overload in children and adolescents across a variety of settings, with a number of potential clinical implications.

中文翻译：

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儿童和青少年的稳态负荷：系统评价。

简介 非稳态负荷的概念涵盖了普通日常生活事件和重大挑战的累积效应，还包括相关的损害健康的行为。当环境挑战超出个人应对能力时，就会出现稳态超载。通过使用生物标志物和临床标准来识别非稳态负荷。关于年轻人群的非稳态负荷的研究越来越多，但缺乏系统评价。目的 本系统评价的目的是总结当前关于儿童和青少年的动态负荷/超负荷的知识。方法 检索了从成立到 2023 年 4 月的 PubMed、PsycINFO、Web of Science 和 Cochrane 图书馆。还对文献进行了手动检索。我们仅考虑在 18 岁以下的临床或非临床人群中充分描述和评估非稳态负荷或超负荷的研究。结果 本次系统评价共纳入 38 项原始研究。研究报告了调节负荷与社会人口特征（例如贫困、种族、感知歧视、不良童年经历）和环境因素之间的关联，以及调节负荷对儿童和青少年身心健康的影响。结论 研究结果表明，在临床和非临床儿科人群中，较大的非稳态负荷与较差的健康结果相关，并可能产生持久影响。结果支持跨诊断识别各种环境下的儿童和青少年的变态负荷和超负荷的临床效用，具有许多潜在的临床意义。