Background In patients with inflammatory bowel disease (IBD), frailty is independently associated with mortality and morbidity. Objectives This study aimed to extend this work to determine the association between the clinical frailty scale (CFS), handgrip strength (HGS), and malnutrition with IBD-related hospitalizations and surgeries. Design IBD patients ⩾18 years of age were prospectively enrolled from two ambulatory care clinics in Alberta, Canada. Methods Frailty was defined as a CFS score ⩾4, dynapenia as HGS < 16 kg for females and <27 kg for males, malnutrition using the subjective global assessment (SGA), and the risk of malnutrition using either the abridged patient-generated SGA (abPG-SGA), or the Saskatchewan Inflammatory Bowel Disease Nutrition Risk Tool (SaskIBD-NRT). Logarithm relative hazard graphs and multivariable logistic regression models adjusting for relevant confounders were constructed. Results One hundred sixty-one patients (35% ulcerative colitis, 65% Crohn's disease) with a mean age of 42.2 (±15.9) years were followed over a mean period of 43.9 (±10.1) months. Twenty-seven patients were hospitalized, and 13 patients underwent IBD-related surgeries following baseline. While the CFS (aHR 1.34; p = 0.61) and SGA (aHR 0.81; p = 0.69) did not independently predict IBD-related hospitalizations, decreased HGS (aHR 3.96; p = 0.03), increased abPG-SGA score (aHR 1.07; p = 0.03) and a SaskIBD-NRT ⩾ 5 (aHR 4.49; p = 0.02) did. No variable was independently associated with IBD-related surgeries. Conclusion HGS, the abPG-SGA, and the SaskIBD-NRT were independently associated with an increased risk of IBD-related hospitalizations. Future studies should aim to validate other frailty assessments in the IBD population in order to better tailor care for all IBD patients.

中文翻译：

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握力和营养不良的风险与炎症性肠病患者住院风险的增加有关。

背景 在炎症性肠病（IBD）患者中，虚弱与死亡率和发病率独立相关。目的 本研究旨在扩展这项工作，以确定临床衰弱量表 (CFS)、握力 (HGS) 和营养不良与 IBD 相关住院和手术之间的关联。设计 18 岁以上的 IBD 患者是从加拿大艾伯塔省的两家门诊护理诊所前瞻性招募的。方法 虚弱被定义为 CFS 评分⩾4，缺乏症被定义为 HGS < 16 kg（女性）和 <27 kg（男性），营养不良使用主观整体评估 (SGA)，营养不良的风险使用患者生成的 SGA ( abPG-SGA），或萨斯喀彻温省炎症性肠病营养风险工具（SaskIBD-NRT）。构建了针对相关混杂因素进行调整的对数相对风险图和多变量逻辑回归模型。结果 对平均年龄 42.2 (±15.9) 岁的 161 名患者（35% 溃疡性结肠炎，65% 克罗恩病）进行了平均 43.9 (±10.1) 个月的随访。27 名患者住院，13 名患者在基线后接受了 IBD 相关手术。虽然 CFS（aHR 1.34；p = 0.61）和 SGA（aHR 0.81；p = 0.69）不能独立预测 IBD 相关住院治疗，但 HGS 降低（aHR 3.96；p = 0.03），abPG-SGA 评分增加（aHR 1.07；p = 0.03）。 p = 0.03），SaskIBD-NRT ⩾ 5（aHR 4.49；p = 0.02）确实如此。没有变量与 IBD 相关手术独立相关。结论 HGS、abPG-SGA 和 SaskIBD-NRT 与 IBD 相关住院风险增加独立相关。未来的研究应旨在验证 IBD 人群的其他虚弱评估，以便更好地为所有 IBD 患者提供量身定制的护理。