Background Adherence to inflammatory bowel disease (IBD) medication is crucial to maintain remission, especially during pregnancy. Objective To examine the influence of family planning and pregnancy-related patient knowledge regarding IBD and pregnancy on adherence. Design Cross-sectional survey study. Methods We surveyed female patients with IBD aged 18-35 years, who at recruitment to the UK IBD BioResource had not had children. We elicited disease and treatment history, demographics and family planning status via an online questionnaire. Patient knowledge as assessed by the validated Crohn's and Colitis Pregnancy Knowledge Score (CCPKnow) and adherence by visual analogue scale (VAS). Results In 326 responders (13.8% response rate), good adherence (VAS ⩾ 80) was found in only 38.35%. Disease- and treatment-related factors were not significantly associated with good adherence, except for methotrexate (70.0% adherent of 10 exposed patients versus 37.2% non-exposed; p = 0.036). Patients planning pregnancy for the next year were more often adherent (59.0% versus 35.5%; p = 0.019) and knowledgeable (median CCPKnow 8 versus 7; p = 0.035) compared to those in other family planning categories. Pregnancy-related patient knowledge was significantly associated with adherence (Pearson correlation 0.141; p = 0.015). Adherent patients had significantly higher CCPKnow scores than non-adherent patients (median 8 versus 6; p = 0.009). On binary regression analysis, only planning to conceive within 12 months was independently associated with better adherence (p = 0.016), but not methotrexate exposure (p = 0.076) and CCPKnow (p = 0.056). Conclusions In a cohort of women of childbearing age with IBD overall medication, adherence was low. Planning to conceive within the next year was associated with better adherence and greater patient knowledge.

中文翻译：

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计划在一年内怀孕与更好的妊娠特异性疾病相关患者知识以及患有炎症性肠病的育龄妇女更好的药物依从性相关。

背景 坚持炎症性肠病 (IBD) 药物治疗对于维持缓解至关重要，尤其是在怀孕期间。目的 探讨计划生育和妊娠相关患者对 IBD 和妊娠的了解对依从性的影响。设计横断面调查研究。方法 我们调查了 18-35 岁的 IBD 女性患者，这些患者在英国 IBD BioResource 招募时尚未生育。我们通过在线调查问卷获取了疾病和治疗史、人口统计数据和计划生育状况。通过经过验证的克罗恩病和结肠炎妊娠知识评分 (CCPKnow) 评估患者的知识，并通过视觉模拟量表 (VAS) 评估患者的依从性。结果 在 326 名应答者中（应答率为 13.8%），只有 38.35% 的患者依从性良好（VAS ⩾ 80）。除甲氨蝶呤外，疾病和治疗相关因素与良好的依从性没有显着相关（10 名暴露患者的依从性为 70.0%，未暴露患者为 37.2%；p = 0.036）。与其他计划生育类别的患者相比，计划明年怀孕的患者通常更坚持（59.0% 对比 35.5%；p = 0.019）并且知识渊博（中位 CCPKnow 8 对比 7；p = 0.035）。患者的妊娠相关知识与依从性显着相关（Pearson 相关性 0.141；p = 0.015）。依从性患者的 CCPKnow 评分显着高于非依从性患者（中位数 8 比 6；p = 0.009）。在二元回归分析中，仅计划在 12 个月内怀孕与更好的依从性独立相关 (p = 0.016)，但与甲氨蝶呤暴露 (p = 0.076) 和 CCPKnow (p = 0.056) 无关。结论 在 IBD 育龄妇女整体用药队列中，依从性较低。计划在明年怀孕与更好的依从性和更多的患者知识相关。