OBJECTIVE This mixed-method pilot study aims to investigate the feasibility and preliminary effects of sport stacking on cognitive function in individuals with mild Alzheimer's disease (AD) and those with mild cognitive impairment (MCI). METHODS Twenty-four community-dwelling subjects with confirmed mild AD or MCI were evenly randomly assigned to either the 12-week sport stacking intervention group (n = 12) or clinic routine management control group (n = 12). Outcome evaluation included the Auditory Verbal Learning Test (AVLT), Alzheimer's Disease Cooperative Study-Activities of Daily Living scale (ADCS-ADL), and plasma brain-derived neurotrophic factor (BDNF). A qualitative descriptive study was conducted to explore the overall perception and experience of the sport stacking from the subjects' perspective. RESULTS Twenty-two subjects completed the trial. At 12 weeks post-intervention, compared to the control group, the sport stacking group had significantly greater improvements in AVLT immediate recall (P < .001, Cohen d = .66) and an increase in plasma BDNF (P < .001, Cohen d = .64). Subgroup analysis indicated that subjects with MCI had significantly greater increases in AVLT immediate recall (P = .005, Cohen d = .72), ADCS-ADL (P = .130, Cohen d = .42) and plasma BDNF (P = .024, Cohen d = .83). Twelve subjects participating in the post-intervention interviews expressed the benefits (e.g., hand-eye coordination and faster reaction) from sport stacking and their enjoyment of it. CONCLUSION To the best of our knowledge, this is the first study indicating that sport stacking is feasible among individuals with MCI and mild AD. The preliminary effect on episodic memory is encouraging, possibly via upregulation of BDNF.

中文翻译：

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运动叠加对轻度阿尔茨海默病和 MCI 患者认知的影响：随机对照试验的初步结果。

目的 这项混合方法试点研究旨在调查综合运动对轻度阿尔茨海默病（AD）和轻度认知障碍（MCI）个体认知功能的可行性和初步影响。方法 将 24 名确诊为轻度 AD 或 MCI 的社区居民受试者均匀随机分配至 12 周运动叠加干预组 (n = 12) 或临床常规管理对照组 (n = 12)。结果评估包括听觉语言学习测试（AVLT）、阿尔茨海默病合作研究-日常生活活动量表（ADCS-ADL）和血浆脑源性神经营养因子（BDNF）。进行了一项定性描述性研究，以从受试者的角度探讨堆叠运动的整体感知和体验。结果 二十二名受试者完成了试验。干预后 12 周时，与对照组相比，运动堆叠组在 AVLT 即时回忆方面有显着更大的改善（P < .001，Cohen d = .66），并且血浆 BDNF 有所增加（P < .001，Cohen） d = .64)。亚组分析表明，MCI 受试者的 AVLT 即刻回忆（P = .005，Cohen d = .72）、ADCS-ADL（P = .130，Cohen d = .42）和血浆 BDNF（P = .42）显着增加。 024，科恩 d = .83)。参与干预后访谈​​的 12 名受试者表达了堆叠运动的好处（例如，手眼协调和更快的反应）以及他们对这项运动的享受。结论 据我们所知，这是第一项表明运动叠加在 MCI 和轻度 AD 患者中可行的研究。对情景记忆的初步影响令人鼓舞，这可能是通过 BDNF 的上调实现的。