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Congenital cleft lip and palate and elevated risks of major psychiatric disorders: A nationwide longitudinal study.
Clinical Child Psychology and Psychiatry ( IF 1.8 ) Pub Date : 2023-09-08 , DOI: 10.1177/13591045231200665 Hsiang-Hsuan Huang,Ju-Wei Hsu,Kai-Lin Huang,Tung-Ping Su,Tzeng-Ji Chen,Shih-Jen Tsai,Mu-Hong Chen
Clinical Child Psychology and Psychiatry ( IF 1.8 ) Pub Date : 2023-09-08 , DOI: 10.1177/13591045231200665 Hsiang-Hsuan Huang,Ju-Wei Hsu,Kai-Lin Huang,Tung-Ping Su,Tzeng-Ji Chen,Shih-Jen Tsai,Mu-Hong Chen
BACKGROUND
Congenital cleft lip and palate (CCLP) may be associated with major psychiatric disorders, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, bipolar disorder, and major depressive disorder.
METHODS
From the Taiwan National Health Insurance Research Database, 1,158 children and adolescents with CCLP and 11,580 age/sex-matched controls without CCLP were included in this study between 2001 and 2010; they were followed up until the end of 2011 to identify the aforementioned major psychiatric disorders.
RESULTS
After adjustment for age, sex, income, residence, and family history, the Cox regression model revealed a positive relationship of CCLP with subsequent schizophrenia (hazard ratio [HR]: 7.60, 95% confidence interval [CI]: 2.03-28.54), ASD (HR: 6.03, 95% CI: 1.76-20.61), and ADHD (HR: 7.33, 95% CI: 5.01-10.73).
DISCUSSION
These findings suggest that clinicians should be attentive to the presence or emergence of mental health conditions in patients with CCLP. Further studies are necessary to investigate the pathogenesis between CCLP and major psychiatric disorders.
更新日期：2023-09-08
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