3D printing technology is an emerging method that gained extensive attention from researchers worldwide, especially in the health and medical fields. Biopolymers are an emerging class of materials offering excellent properties and flexibility for additive manufacturing. Biopolymers are widely used in biomedical applications in biosensing, immunotherapy, drug delivery, tissue engineering and regeneration, implants, and medical devices. Various biodegradable and non-biodegradable polymeric materials are considered as bio-ink for 3d printing. Here, we offer an extensive literature review on the current applications of synthetic biopolymers in the field of 3D printing. A trend in the publication of biopolymers in the last 10 years are focused on the review by analyzing more than 100 publications. Their application and classification based on biodegradability are discussed. The various studies, along with their practical applications, are elaborated in the subsequent sections for polyethylene, polypropylene, polycaprolactone, polylactide, etc. for biomedical applications. The disadvantages of various biopolymers are discussed, and future perspectives like combating biocompatibility problems using 3D printed biomaterials to build compatible prosthetics are also discussed and the potential application of using resin with the combination of biopolymers to build customized implants, personalized drug delivery systems and organ on a chip technologies are expected to open a new set of chances for the development of healthcare and regenerative medicine in the future.

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合成生物聚合物在生物医学3D打印中的最新应用综述

3D打印技术是一种新兴方法，得到了全世界研究人员的广泛关注，特别是在健康和医疗领域。生物聚合物是一类新兴材料，为增材制造提供卓越的性能和灵活性。生物聚合物广泛应用于生物传感、免疫治疗、药物输送、组织工程和再生、植入物和医疗设备等生物医学应用。各种可生物降解和不可生物降解的聚合物材料被认为是用于3D打印的生物墨水。在这里，我们对合成生物聚合物在 3D 打印领域的当前应用进行了广泛的文献综述。过去10年生物聚合物出版物的一个趋势是通过分析100多篇出版物来进行综述。讨论了它们的应用和基于生物降解性的分类。各种研究及其实际应用将在后续章节中针对生物医学应用的聚乙烯、聚丙烯、聚己内酯、聚丙交酯等进行详细阐述。讨论了各种生物聚合物的缺点，并讨论了未来的前景，例如使用 3D 打印生物材料构建兼容的假肢来解决生物相容性问题，以及使用树脂与生物聚合物的组合来构建定制植入物、个性化药物输送系统和器官的潜在应用芯片技术有望为未来医疗保健和再生医学的发展带来新的机遇。

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