Leucine-rich repeat kinase 2 (LRRK2) is a multidomain scaffolding protein with dual guanosine triphosphatase (GTPase) and kinase enzymatic activities, providing this protein with the capacity to regulate a multitude of signalling pathways and act as a key mediator of diverse cellular processes. Much of the interest in LRRK2 derives from mutations in the LRRK2 gene being the most common genetic cause of Parkinson's disease, and from the association of the LRRK2 locus with a number of other human diseases, including inflammatory bowel disease. Therefore, the LRRK2 research field has focused on the link between LRRK2 and pathology, with the aim of uncovering the underlying mechanisms and, ultimately, finding novel therapies and treatments to combat them. From the biochemical and cellular functions of LRRK2, to its relevance to distinct disease mechanisms, this Cell Science at a Glance article and the accompanying poster deliver a snapshot of our current understanding of LRRK2 function, dysfunction and links to disease.

中文翻译：

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富含亮氨酸的重复激酶 2 一目了然。

富含亮氨酸的重复激酶 2 (LRRK2) 是一种多结构域支架蛋白，具有双鸟苷三磷酸酶 (GTPase) 和激酶酶活性，使该蛋白能够调节多种信号通路并充当多种细胞过程的关键介质。人们对 LRRK2 的兴趣很大程度上源于 LRRK2 基因的突变（帕金森病最常见的遗传原因），以及 LRRK2 基因座与许多其他人类疾病（包括炎症性肠病）的关联。因此，LRRK2研究领域重点关注LRRK2与病理学之间的联系，旨在揭示其潜在机制，并最终找到新的疗法和疗法来对抗它们。从 LRRK2 的生化和细胞功能，到其与不同疾病机制的相关性，这篇《细胞科学概览》文章和随附的海报概述了我们目前对 LRRK2 功能、功能障碍以及与疾病的联系的理解。