Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease that involves host genetics, the microbiome, and inflammatory responses. The current consensus is that the disruption of the intestinal mucosal barrier is the core pathogenesis of IBD, including intestinal microbial factors, abnormal immune responses, and impaired intestinal mucosal barrier. Cumulative data show that nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are dominant mediators in maintaining the homeostasis of the intestinal mucosal barrier, which play critical roles in sensing the commensal microbiota, maintaining homeostasis, and regulating intestinal inflammation. Blocking NLRs inflammasome activation by botanicals may be a promising way to prevent IBD progression. In this review, we systematically introduce the multiple roles of NLRs in regulating intestinal mucosal barrier homeostasis and focus on summarizing the activities and potential mechanisms of natural products against IBD. Aiming to propose new directions on the pathogenesis and precise treatment of IBD.

中文翻译：

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NOD 样受体介导稳态肠上皮屏障功能：炎症性肠病的有希望的治疗靶点。

炎症性肠病 (IBD) 是一种慢性胃肠道炎症性疾病，涉及宿主遗传学、微生物组和炎症反应。目前的共识认为，肠黏膜屏障破坏是IBD的核心发病机制，包括肠道微生物因素、免疫反应异常、肠黏膜屏障受损等。累积数据表明，核苷酸结合和寡聚结构域（NOD）样受体（NLR）是维持肠粘膜屏障稳态的主要介质，在感知共生微生物群、维持稳态和调节肠道炎症方面发挥着关键作用。通过植物药阻断 NLR 炎症小体激活可能是预防 IBD 进展的一种有前途的方法。在这篇综述中，我们系统地介绍了NLRs在调节肠粘膜屏障稳态中的多种作用，并重点总结了天然产物抗IBD的活性和潜在机制。旨在为IBD的发病机制和精准治疗提出新方向。