Recently, several studies have explored inflammatory biomarkers associated with colorectal neoplasms in human plasma and investigated the prognostic value of systemic cytokine profiles and inflammatory markers in colorectal cancer. However, little is known about inflammatory biomarkers in colorectal adenoma and early cancer. We compared the level of 38 inflammatory markers in the plasma of 112 adenoma patients, 72 Tis`T1 staging of colorectal carcinoma patients, 34 T2-T4 staging of colorectal carcinoma patients and 53 normal subjects. In summary, we found that eight inflammatory biomarkers (Eotaxin, GCSF, IL-4, IL-5, IL-17E, MCP-1, TNF-alpha, VEGF-A) have higher plasma concentrations in colorectal adenoma and cancer patients compared to normal participants over 50 years old and may have the prognostic value for colorectal adenoma and early -stage carcinoma.

中文翻译：

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新血浆炎症标志物与 50 岁以上个体结直肠肿瘤风险之间的关联。

最近，一些研究探索了人血浆中与结直肠肿瘤相关的炎症生物标志物，并研究了结直肠癌中全身细胞因子谱和炎症标志物的预后价值。然而，人们对结直肠腺瘤和早期癌症的炎症生物标志物知之甚少。我们比较了112名腺瘤患者、72名Tis`T1分期结直肠癌患者、34名T2-T4分期结直肠癌患者和53名正常人血浆中38种炎症标志物的水平。总之，我们发现八种炎症生物标志物（Eotaxin、GCSF、IL-4、IL-5、IL-17E、MCP-1、TNF-α、VEGF-A）在结直肠腺瘤和癌症患者中的血浆浓度高于结直肠腺瘤和癌症患者。 50岁以上的正常参与者，可能对结直肠腺瘤和早期癌具有预后价值。