INTRODUCTION To investigated the safety and efficacy of emergency stenting for patients with ischemic stroke treated with bridging therapy. METHODS Patients with onset of stroke who underwent bridging therapy were included in the two groups with emergency stenting (ESG) and without stenting (NSG). To avoid the bias due to confounding variables, subjects were further assigned in two groups using 1:1 propensity score matching (PSM). The safety outcomes include the incidence of intracranial hemorrhage (ICH), parenchymal hemorrhage type 2 (PH2), symptomatic intracranial hemorrhage (sICH), fatal hemorrhage, and mortality. The efficacy outcomes include successful recanalization, three-month favorable outcome (modified Rankin Scale [mRS]: 0-2). RESULTS 175 patients treated with bridging therapy were included in this study, with 52 patients in the ES group and 123 patients in the groups without ES, and with 30 patients in each group after PSM. No significant differences in the incidences of ICH, PH2, sICH, fatal hemorrhage, and mortality were found between the two groups with ES and without ES before and after PSM (P>0.05 for all groups). The analysis without PSM showed that the group with ES had a higher rate of successful recanalization (98.1% vs. 81.6%，P=0.041) than the group without ES, but no significant difference was seen (96.6% vs. 93.3%，P=0.554) between the two groups after PSM. There was no difference in favorable outcome between the two groups before and after matching as well (P>0.05). CONCLUSIONS It is safe and effective for patients with onset of ischemic stroke to receive emergency stenting during bridging therapy, without increasing the risk of hemorrhagic transformation and mortality.

中文翻译：

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桥接治疗期间紧急支架置入术的安全性和有效性：单中心回顾性研究。

简介 旨在调查接受桥接治疗的缺血性卒中患者紧急支架置入术的安全性和有效性。方法 接受桥接治疗的卒中发作患者被纳入紧急支架置入术（ESG）和不支架置入术（NSG）两组。为了避免混杂变量造成的偏差，使用 1:1 倾向评分匹配 (PSM) 将受试者进一步分配为两组。安全性结果包括颅内出血 (ICH)、2 型实质出血 (PH2)、症状性颅内出血 (sICH)、致命性出血和死亡率的发生率。疗效结果包括成功的再通、三个月的良好结果（改良Rankin量表[mRS]：0-2）。结果本研究纳入175例接受桥接治疗的患者，其中ES组52例，无ES组123例，PSM后各组30例。PSM前后，有ES组和无ES组的ICH、PH2、sICH、致命性出血和死亡率的发生率差异均无统计学意义（各组均P>0.05）。未行PSM分析显示，有ES组再通成功率（98.1% vs. 81.6%，P=0.041）高于无ES组，但差异无统计学意义（96.6% vs. 93.3%，P=0.041）。 =0.554) PSM 后两组之间的差异。两组配型前后的良好结局也无差异（P>0.05）。结论 对于缺血性脑卒中发作的患者在桥接治疗期间接受紧急支架置入术是安全有效的，不会增加出血转化和死亡的风险。