Background Baicalin has been shown to promote spatial learning and neural regeneration, which might increase the differentiation of neural stem cells in Alzheimer's disease (AD) rat models. We aimed to study the role of baicalin on neuronal pentraxin-1 (NPTX-1), neuronal pentraxin-2 (NPTX-2), and C-reactive protein (CRP) in AD model rats. Methods The 30 male Sprague Dawley rats were divided into three groups: the control group, the AD model group, and the AD + baicalin group. Then, the Morris water maze was used to verify the effect of baicalin on the memory and spatial learning of rats. Immunohistochemistry and immunofluorescence were used to observe the expression of NPTX-1, NPTX-2, and CRP in brain tissue. Results Compared with the AD model group, the AD rats treated with baicalin spent significantly less time finding escape latencies (P = 0.008) and had longer cross-platform times in the target quadrant (P = 0.015). In addition, the AD + baicalin group had significantly higher numbers of hippocampal neurons compared with the AD model group (P < 0.05). Baicalin also obviously decreased the apoptosis of neurons. Moreover, compared with the AD model group, the NPTX-1 and CRP expression in the AD + baicalin group was significantly reduced (P = 0.000) while the expression of NPTX-2 in the brain tissue of AD rats was significantly increased (P = 0.000). Conclusions Baicalin can play a therapeutic role by downregulating NPTX-1, upregulating NPTX-2, and downregulating CPR in AD model rats.

中文翻译：

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黄芩苷对阿尔茨海默病大鼠模型神经元pentraxin-1、神经元pentraxin-2和C反应蛋白的干预研究。

背景黄芩苷已被证明可以促进空间学习和神经再生，这可能会增加阿尔茨海默病 (AD) 大鼠模型中神经干细胞的分化。我们的目的是研究黄芩苷对 AD 模型大鼠神经元五聚蛋白-1 (NPTX-1)、神经元五聚蛋白-2 (NPTX-2) 和 C 反应蛋白 (CRP) 的作用。方法将30只雄性SD大鼠分为3组：对照组、AD模型组、AD+黄芩苷组。然后利用Morris水迷宫验证黄芩苷对大鼠记忆和空间学习的影响。采用免疫组化和免疫荧光法观察脑组织中NPTX-1、NPTX-2、CRP的表达情况。结果与AD模型组相比，黄芩苷治疗的AD大鼠寻找逃避潜伏期的时间显着减少（P=0.008），并且在目标象限的跨平台时间更长（P=0.015）。此外，AD+黄芩苷组海马神经元数量显着高于AD模型组（P < 0.05）。黄芩苷还明显减少神经元的凋亡。而且,与AD模型组相比,AD+黄芩苷组AD大鼠脑组织中NPTX-1、CRP的表达量显着降低(P=0.000),而NPTX-2的表达量显着升高(P=0.000)。 0.000）。结论 黄芩苷可通过下调NPTX-1、上调NPTX-2、下调CPR对AD模型大鼠发挥治疗作用。