Generating A-to-C transversions to correct defective alleles or introduce novel alleles has posed significant challenges. However, two recent studies focusing on adenine transversions have achieved successful A-to-C transversions in mouse embryos and plant cell. These remarkable accomplishments notably broaden the range of base editing and their applications both in fundamental research and in therapeutics.

中文翻译：

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通过腺嘌呤颠换编辑器进行高效的 A·T 到 C·G 碱基编辑。

产生 A 到 C 的颠换来纠正有缺陷的等位基因或引入新的等位基因已经提出了重大挑战。然而，最近两项关注腺嘌呤颠换的研究已经在小鼠胚胎和植物细胞中成功实现了 A 到 C 的颠换。这些非凡的成就显着扩大了碱基编辑的范围及其在基础研究和治疗学中的应用。