Prevalence and Risk Factors of Cerebral Small Vessel Disease from a Population-Based Cohort in China.,Neuroepidemiology

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Prevalence and Risk Factors of Cerebral Small Vessel Disease from a Population-Based Cohort in China.
Neuroepidemiology ( IF 5.7 ) Pub Date : 2023-09-21 , DOI: 10.1159/000533678
Yingying Yang _{1,

2} , Xueli Cai ₃ , Mengyuan Zhou _{4,

5} , Yiyi Chen _{4,

5} , Jingtao Pi _{4,

5} , Mengxi Zhao _{4,

5} , Yulu Shi _{4,

5} , Suying Wang ₆ , Jing Jing _{4,

5} , Weiqi Chen _{4,

5} , Xia Meng _{4,

5} , Yongjun Wang _{4,

5} , Yuesong Pan _{4,

5} , Yilong Wang _{4,

5,

7,

8,

9}

Affiliation

INTRODUCTION Cerebral small vessel disease (CSVD) is a significant burden of morbidity and mortality among elderly people around the world. Epidemiological data with complete CSVD evaluations and a large sample size in the general population are still limited. METHODS Community-dwelling residents in Lishui city in China from the cross-sectional survey of the PRECISE study (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) were included in this study from 2017 to 2019. All participants underwent 3 Tesla brain magnetic resonance images to assess CSVD imaging markers. Demographic and risk factor data were collected. The general and age-specific prevalence of lacune, confluent white matter hyperintensity (WMH), moderate-severe enlarged perivascular spaces (EPVS), cerebral microbleed (CMB), and total CSVD score ( an ordinal scale from 0 to 4, counting the presence of four imaging markers of CSVD) was evaluated. Associations between vascular risk factors and these markers were analyzed by multivariable logistic regression. RESULTS A total of 3063 participants were enrolled. The mean age was 61.2 years and 46.5% were men. The most prevalent CSVD marker was confluent WMH (16.7%), followed by CMB (10.2%), moderate-severe EPVS in the basal ganglia (BG-EPVS) (9.8%), and lacune (5.6%). 30.5% of the participants have at least one of the four markers (total CSVD score ≥ 1 points). The prevalence of CSVD markers increases as the age increases. Age and hypertension were independent risk factors for four CSVD markers and the total CSVD score. CONCLUSIONS In this Chinese cohort with community-based adults aged 50 to 75 years, our findings showed a prevalence of 30.5% for CSVD. The most prevalent CSVD marker was confluent WMH, followed by CMB, moderate-severe BG-EPVS and lacune. The risk factors for CSVD must be strictly screened and controlled in adults living in the community.

更新日期：2023-09-21

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