: The antibacterial and antiviral functions of human defensin 5 lay the foundation for its role as a core host protective component. In addition, HD5 also has the function of inhibiting tumor proliferation and immune regulation. However, everything has two sides; cytotoxic and proinflammatory properties may exist, while HD5 performs physiological functions. Accordingly, the modification and engineering of HD5 are particularly important. Therefore, this review summarizes the role of HD5 in various aspects of host defense, as well as modification of HD5 to ameliorate the biological activity, with a view to promoting the clinical use of HD5.

中文翻译：

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人类防御素5的功能和修饰

：人防御素5的抗菌和抗病毒功能为其作为核心宿主保护成分奠定了基础。此外，HD5还具有抑制肿瘤增殖和免疫调节的功能。然而，任何事情都有两个方面；可能存在细胞毒性和促炎特性，而 HD5 则发挥生理功能。因此，HD5的改造和工程化就显得尤为重要。因此，本文综述了HD5在宿主防御各方面的作用，以及对HD5进行修饰以改善其生物活性，以期促进HD5的临床应用。