Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer,Endocrine Connections

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Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer
Endocrine Connections ( IF 2.9 ) Pub Date : 2024-01-01 , DOI: 10.1530/ec-23-0373
Yuting Shao ₁ , Xiaole Hu ₂ , Yuxi Wang ₃ , Yi Shao ₄ , Luchuan Li ₄ , Qingdong Zeng ₄ , Hong Lai ₁ , Lei Sheng ₄

Affiliation

Objective

Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicopathologic features of PTC.

Methods

Patients who underwent thyroidectomy were retrospectively reviewed. Serum 25(OH)D levels were measured within a week prior to surgery. The patients were categorized into four quartiles according to season-specific 25(OH)D levels. The association between 25(OH)D levels and clinicopathologic features of PTC was analyzed.

Results

A total of 2932 patients were enrolled in the study. The 25(OH)D levels were significantly higher in patients with lymph node metastasis (LNM; P < 0.001), lateral LNM (P < 0.001), and multifocal tumors (P < 0.001). Compared to the first quartile (Q1) of 25(OH)D level, the third quartile (Q3) and the fourth quartile (Q4) showed an unadjusted OR of 1.36 (95% CI: 1.09–1.69; P = 0.006) and 1.76 (95% CI: 1.42–2.19; P < 0.001) for LNM (P for trend < 0.001), respectively. An increased risk of multifocal tumors was strongly associated with high 25(OH)D concentration (P for trend <0.001). Similar results were obtained after adjusting for confounding factors.

Conclusion

High 25(OH)D levels are associated with aggressive features of PTC, such as lymph node metastasis and multifocality.

中文翻译：

血清 25-羟基维生素 D 水平与甲状腺乳头状癌侵袭性的关系

客观的

已知血清 25-羟基维生素 D (25(OH)D) 缺乏与多种癌症的风险和死亡率有关。然而，25(OH)D 在甲状腺乳头状癌 (PTC) 中的作用仍存在争议。本研究旨在探讨 25(OH)D 与 PTC 临床病理特征之间的关联。

方法

对接受甲状腺切除术的患者进行回顾性分析。手术前一周内测量血清 25(OH)D 水平。根据特定季节的 25(OH)D 水平，将患者分为四个四分位数。分析了 25(OH)D 水平与 PTC 临床病理特征之间的关联。

结果

共有 2932 名患者参加了该研究。淋巴结转移（LNM；P < 0.001）、外侧LNM（P < 0.001）和多灶性肿瘤（P < 0.001）患者的25（OH）D水平显着升高。与 25(OH)D 水平的第一个四分位数 (Q1) 相比，第三个四分位数 (Q3) 和第四个四分位数 (Q4) 显示未经调整的 OR 分别为 1.36（95% CI：1.09–1.69；P = 0.006）和 1.76 LNM 分别为（95% CI：1.42–2.19；P < 0.001）（趋势P < 0.001）。多灶性肿瘤风险增加与高 25(OH)D 浓度密切相关（趋势P <0.001）。调整混杂因素后得到了类似的结果。