Background Given that associations of Life’s Essential 8 (LE8) and cerebral small vessel disease (CSVD) or its imaging markers were unclear, we examined relationship between them. Methods The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study. We calculated the total LE8 score, medical LE8 score and behavioural score, and categorised them into low (<60), moderate (60–79) or high (≥80) group. MRI markers included lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces in basal ganglia (BG-EPVS) and cerebral microbleeds (CMB). In respect of, total CSVD score (0–4 points), WMH, lacunes or CMB were categorised as two grades, and BG-EPVS (N>10) was allocated one point. Based on modified total CSVD score (0–6 points), WMH or CMB was modified to three grades, and BG-EPVS (N>20) was allocated one point. Results Among 3061 participants in this study, 1424 (46.5%) were male. Higher LE8 score was associated with lower total CSVD score (moderate vs low: cOR 0.78, 95% CI 0.63 to 0.96; high vs low: cOR 0.44, 95% CI 0.33 to 0.59), and the medical score was inversely related to the total CSVD score. Furthermore, the medical score was inversely related to odds of WMH (p<0.05), modified WMH (p<0.05), lacunes (p<0.05) or BG-EPVS (p<0.05), and the behavioural score were inversely related to the odds of lacunes and BG-EPVS. Conclusions Higher LE8 score which indicates better cardiovascular status was associated with lower burden of CSVD and its MRI markers. Longitudinal studies are needed to examine the causality. Data are available on reasonable request. The data are available to researchers on reasonable request from the corresponding author.

中文翻译：

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生命要素8与脑小血管疾病的关联

背景 鉴于生命必需 8 (LE8) 与脑小血管疾病 (CSVD) 或其影像学标志物的关联尚不清楚，我们检查了它们之间的关系。方法 横断面研究包括来自认知障碍多血管评估和血管事件研究的社区居民。我们计算了 LE8 总分、医学 LE8 分数和行为分数，并将其分为低（<60）、中（60-79）或高（≥80）组。MRI 标志物包括腔隙、白质高信号 (WMH)、基底神经节血管周围间隙扩大 (BG-EPVS) 和脑微出血 (CMB)。CSVD总分（0-4分），WMH、腔隙或CMB分为两级，BG-EPVS（N>10）分一分。根据修改后的CSVD总分（0-6分），将WMH或CMB修改为三个等级，BG-EPVS（N>20）分配1分。结果 在本研究的 3061 名参与者中，1424 名（46.5%）为男性。较高的 LE8 评分与较低的 CSVD 总评分相关（中度与低度：cOR 0.78，95% CI 0.63 至 0.96；高与低度：cOR 0.44，95% CI 0.33 至 0.59），并且医疗评分与总评分呈负相关。 CSVD 评分。此外，医疗评分与 WMH (p<0.05)、改良 WMH (p<0.05)、腔隙 (p<0.05) 或 BG-EPVS (p<0.05) 的几率呈负相关，行为评分与腔隙和 BG-EPVS 的几率。结论 较高的 LE8 评分表明较好的心血管状况，与较低的 CSVD 及其 MRI 标志物负担相关。需要进行纵向研究来检验因果关系。可根据合理要求提供数据。这些数据可根据通讯作者的合理要求提供给研究人员。