Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory, osteolytic bone disorder sometimes localized to a unifocal site in the jaw, causing long-term pain and reduced function. The aim of this study was to describe the patients with CNO of the jaw, focusing on treatment with zoledronic acid for pain relief. An analysis of medical records of 24 patients with CNO of the jaw, including treatment with zoledronic acid and effects on pain relief. Descriptive statistics and nonparametric tests were used to describe the population and compare treatment effects, respectively. The average treatment period was 33.4 months (median 23; Q1 11.5; Q3 42.0) with an average of 4.1 infusions (median 3; Q1 2; Q3 5) of zoledronic acid. The average pain VAS score (visual analogue scale) was significantly reduced from 7.7 (median 8; Q1 6.5; Q3 8.5) to 2.5 points (median 2; Q1 0.5; Q3 4.5) (p < 0.001). At final visit, 46% of patients reported no pain and 38% reported a reduction of pain. At least 67% of patients had at least one episode of pain recurrence, and most patients experienced the first recurrence within a year of initial treatment. Four patients (16%) had no pain relief from the treatment. In this group of patients with CNO of the jaw, there was a positive response to treatment with zoledronic acid on pain relief, averaging 5.2 points on a pain VAS score, with 84% of patients treated experiencing either a partial or a total reduction in pain after about 2.5 years.

慢性非细菌性骨髓炎 (CNO) 是一种自身炎症性溶骨性骨病，有时局限于颌骨的单一部位，导致长期疼痛和功能下降。本研究的目的是描述下颌 CNO 患者，重点关注唑来膦酸缓解疼痛的治疗。对 24 例颌骨 CNO 患者的病历进行分析，包括唑来膦酸的治疗和缓解疼痛的效果。描述性统计和非参数检验分别用于描述人群和比较治疗效果。平均治疗时间为 33.4 个月（中位数 23；第一季度 11.5；第三季度 42.0），平均输注 4.1 次唑来膦酸（中位数 3；第一季度 2；第三季度 5）。平均疼痛 VAS 评分（视觉模拟评分）从 7.7（中位数 8；Q1 6.5；Q3 8.5）显着降低至 2.5 分（中位数 2；Q1 0.5；Q3 4.5）（p < 0.001）。在最后一次就诊时，46% 的患者报告没有疼痛，38% 的患者报告疼痛减轻。至少 67% 的患者至少有一次疼痛复发，大多数患者在初次治疗一年内经历了第一次复发。四名患者 (16%) 治疗后疼痛没有缓解。在这组下颌 CNO 患者中，唑来膦酸治疗对疼痛缓解有积极反应，疼痛 VAS 评分平均为 5.2 分，84% 的治疗患者疼痛部分或全部减轻大约2.5年后。