BACKGROUND The discriminative utility of the neonatal sequential organ failure assessment (nSOFA) for early-onset sepsis (EOS) mortality in the neonatal intensive care unit (NICU) is unknown. OBJECTIVES The objective of the study was to determine the utility of nSOFA for EOS mortality. METHODS Multicenter, retrospective cohort study of NICU patients with EOS between 2012 and 2023. nSOFA scores of survivors and non-survivors were compared, and area under the receiver operating characteristics curve (AUROC) for mortality was calculated. RESULTS 104 subjects were identified (88 lived, 16 died). AUROC at blood culture collection (T0), 6 h after collection (T6), and the maximum nSOFA at T0 or T6 (T0-6max) were 0.76 (95% CI: 0.62, 0.91), 0.89 (0.80, 0.99), and 0.87 (0.77, 0.97), respectively. Analyses restricted to birthweight (<1.5, <1 kg) or gestational age (<32, <29 week) cutoffs revealed AUROC ranges of 0.86-0.92 for T6 and 0.82-0.84 for T0-6max. CONCLUSIONS The nSOFA showed good-to-excellent discrimination of mortality among infants with EOS in the NICU.

中文翻译：

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早发型感染新生儿序贯器官衰竭评估和死亡风险评估。

背景 新生儿序贯器官衰竭评估（nSOFA）对新生儿重症监护病房（NICU）早发败血症（EOS）死亡率的区分效用尚不清楚。目的 本研究的目的是确定 nSOFA 对 EOS 死亡率的效用。方法 对 2012 年至 2023 年 NICU EOS 患者进行多中心、回顾性队列研究。比较幸存者和非幸存者的 nSOFA 评分，并计算死亡率的受试者工作特征曲线下面积 (AUROC)。结果 确定了 104 名受试者（88 名存活，16 名死亡）。血培养物采集时 (T0)、采集后 6 小时 (T6) 的 AUROC 以及 T0 或 T6 时的最大 nSOFA (T0-6max) 分别为 0.76 (95% CI: 0.62, 0.91)、0.89 (0.80, 0.99) 和分别为 0.87（0.77、0.97）。仅限于出生体重（<1.5、<1 kg）或胎龄（<32、<29 周）截止值的分析显示，T6 的 AUROC 范围为 0.86-0.92，T0-6max 的 AUROC 范围为 0.82-0.84。结论 nSOFA 对 NICU 中 EOS 婴儿的死亡率表现出良好至优秀的区分度。