OBJECTIVE Precision medicine is an area with great potential for mental health, but has made limited gains prognostically in predicting effective treatments. For refugees exposed to violence, culture may be a crucial factor in predicting treatment outcomes. METHOD For this study, 290 participants from three regions (Afghanistan, the Great Lakes region of Africa, and Iraq and Syria) participated in a randomized controlled trial of an advocacy-based intervention. Emotional distress symptoms were measured prior to intervention, midintervention (3 months), postintervention (6 months), and follow-up (6 months after the end of intervention). Number of traumatic events, resource access, social support, and English proficiency were tested for potential predictive effects on intervention outcome. RESULTS Multilevel generalized linear models revealed that Afghans' (B = -0.259, SE = 0.108, p = .013), and Great Lakes Africans' (B = -0.116, SE = 0.057, p = .042) emotional distress symptoms improved as a function of the intervention, while Iraqis and Syrians showed no intervention effects. For Afghans, English proficiency (B = -0.453, SE = 0.157, p < .01) and social support (B = -0.179, SE = 0.086, p = .037) were most strongly correlated to emotional distress, while for Africans, resource access (B = -0.483, SE = 0.082, p < .001) and social support (B = -0.100, SE = 0.048, p = .040) were the strongest predictors of emotional distress. CONCLUSIONS Response to advocacy-based interventions and active ingredients may be influenced by culture; findings have implications for refugees and precision medicine. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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基于倡导的干预措施中三个难民群体心理健康结果的预测因素：精准医学视角。

目标 精准医学是一个在心理健康方面具有巨大潜力的领域，但在预测有效治疗方面取得的进展有限。对于遭受暴力的难民来说，文化可能是预测治疗结果的关键因素。方法 在本研究中，来自三个地区（阿富汗、非洲大湖地区、伊拉克和叙利亚）的 290 名参与者参加了一项基于宣传的干预措施的随机对照试验。在干预前、干预中期（3个月）、干预后（6个月）和随访（干预结束后6个月）测量情绪困扰症状。测试了创伤事件的数量、资源获取、社会支持和英语水平对干预结果的潜在预测作用。结果 多级广义线性模型显示，阿富汗人（B = -0.259，SE = 0.108，p = .013）和五大湖区非洲人（B = -0.116，SE = 0.057，p = .042）的情绪困扰症状随着干预的作用，而伊拉克人和叙利亚人没有表现出干预效果。对于阿富汗人来说，英语水平（B = -0.453，SE = 0.157，p < .01）和社会支持（B = -0.179，SE = 0.086，p = .037）与情绪困扰的相关性最强，而对于非洲人来说，资源获取（B = -0.483，SE = 0.082，p < .001）和社会支持（B = -0.100，SE = 0.048，p = .040）是情绪困扰的最强预测因素。结论 对基于宣传的干预措施和活性成分的反应可能会受到文化的影响；研究结果对难民和精准医疗具有影响。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。