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New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-11-23 , DOI: 10.1080/14756366.2023.2281260 Assem Barakat 1 , Saeed Alshahrani 1 , Abdullah Mohammed Al-Majid 1 , Abdullah Saleh Alamary 1 , Matti Haukka 2 , Marwa M Abu-Serie 3 , Luis R Domingo 4 , Sajda Ashraf 5 , Zaheer Ul-Haq 5 , Mohamed S Nafie 6, 7 , Mohamed Teleb 8
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2023-11-23 , DOI: 10.1080/14756366.2023.2281260 Assem Barakat 1 , Saeed Alshahrani 1 , Abdullah Mohammed Al-Majid 1 , Abdullah Saleh Alamary 1 , Matti Haukka 2 , Marwa M Abu-Serie 3 , Luis R Domingo 4 , Sajda Ashraf 5 , Zaheer Ul-Haq 5 , Mohamed S Nafie 6, 7 , Mohamed Teleb 8
Affiliation
Despite the crucial role of CDK2 in tumorigenesis, few inhibitors reached clinical trials for managing lung cancer, the leading cause of cancer death. Herein, we report combinatorial stereoselectiv...
中文翻译：
新型螺茚并[1,2-b]喹喔啉与苯并咪唑支架结合作为 CDK2 抑制剂，用于阻止非小细胞肺癌；立体选择性合成、分子动力学和结构见解
尽管CDK2在肿瘤发生中发挥着至关重要的作用，但很少有抑制剂能够进入治疗肺癌（癌症死亡的主要原因）的临床试验。在此，我们报告了组合立体选择性...
更新日期：2023-11-23
中文翻译：
新型螺茚并[1,2-b]喹喔啉与苯并咪唑支架结合作为 CDK2 抑制剂，用于阻止非小细胞肺癌；立体选择性合成、分子动力学和结构见解
尽管CDK2在肿瘤发生中发挥着至关重要的作用，但很少有抑制剂能够进入治疗肺癌（癌症死亡的主要原因）的临床试验。在此，我们报告了组合立体选择性...
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