Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for mitigating brain injury after ischemic stroke. TRP channels are evolutionally ancient biosensors that detect external stimuli as well as tissue or cellular injury. To date, many members of the TRP superfamily have been reported to contribute to ischemic brain injury, including the TRPC subfamily (1, 3, 4, 5, 6, 7), TRPV subfamily (1, 2, 3, 4) and TRPM subfamily (2, 4, 7). These TRP channels share structural similarities but have distinct channel functions and properties. Their activation during ischemic stroke can be beneficial, detrimental, or even both. In this review, we focus on discussing the interesting features of stroke-related TRP channels and summarizing the underlying cellular and molecular mechanisms responsible for their involvement in ischemic brain injury.

缺血性中风是一种毁灭性的疾病，影响着全世界数百万患者。不幸的是，没有有效的药物可以减轻缺血性中风后的脑损伤。TRP 通道是进化上古老的生物传感器，可检测外部刺激以及组织或细胞损伤。迄今为止，TRP 超家族的许多成员已被报道可导致缺血性脑损伤，包括 TRPC 亚家族 (1, 3, 4, 5, 6, 7)、TRPV 亚家族 (1, 2, 3, 4) 和 TRPM亚科（2、4、7）。这些 TRP 通道具有结构相似性，但具有不同的通道功能和特性。它们在缺血性中风期间的激活可能是有益的，也可能是有害的，甚至两者兼而有之。在这篇综述中，我们重点讨论中风相关 TRP 通道的有趣特征，并总结其参与缺血性脑损伤的潜在细胞和分子机制。