Worldwide, type 2 diabetes is predominant form of diabetes, and it is mainly affected by the environment. Furthermore, the offspring of patients with type 2 diabetes and metabolic disorder syndrome may have a higher risk of diabetes and cardiovascular disease, which indicates that the environmental impact on diabetes prevalence can be transmitted across generations. In the process of diabetes onset and intergenerational transmission, the genetic structure of the individual is not directly changed but is regulated by epigenetics. In this process, genes or histones are modified, resulting in selective expression of proteins. This modification will affect not only the onset of diabetes but also the related onset of atherosclerosis. Acetylation and deacetylation may be important regulatory factors for the above lesions. Therefore, in this review, based on the whole process of atherosclerosis evolution, we explored the possible existence of acetylation/deacetylation caused by diabetes. However, due to the lack of atherosclerosis-related acetylation studies directly based on diabetic models, we also used a small number of experiments involving nondiabetic models of related molecular mechanisms.

中文翻译：

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乙酰化组蛋白修饰：糖尿病和动脉粥样硬化的交叉点。

在世界范围内，2型糖尿病是糖尿病的主要形式，并且主要受环境影响。此外，2型糖尿病和代谢紊乱综合症患者的后代可能有更高的糖尿病和心血管疾病风险，这表明环境对糖尿病患病率的影响可以代代相传。在糖尿病发病和代际传递的过程中，个体的遗传结构并没有直接改变，而是受到表观遗传学的调控。在此过程中，基因或组蛋白被修饰，导致蛋白质的选择性表达。这种改变不仅会影响糖尿病的发病，还会影响相关的动脉粥样硬化的发病。乙酰化和脱乙酰化可能是上述病变的重要调节因素。因此，本综述基于动脉粥样硬化演变的全过程，探讨了糖尿病引起的乙酰化/脱乙酰化的可能存在。但由于缺乏直接基于糖尿病模型的动脉粥样硬化相关乙酰化研究，我们还使用了少量涉及非糖尿病模型的相关分子机制的实验。