INTRODUCTION Differences in eosinophilic esophagitis (EoE) presentation and outcomes by ethnicity or race remain understudied. We aimed to determine whether EoE patients of Hispanic/Latinx ethnicity or non-White race have differences in presentation at diagnosis or response to topical corticosteroid (tCS) treatment. METHODS This retrospective cohort study included subjects of any age with a new diagnosis of EoE and documentation of ethnicity or race. For those who had treatment with tCS and follow-up endoscopy/biopsy, we assessed histologic response (<15 eosinophils/hpf), global symptom response, and endoscopic response. Hispanic EoE patients were compared with non-Hispanics at baseline and before and after treatment. The same analyses were repeated for White vs non-Whites. RESULTS Of 1,026 EoE patients with ethnicity data, just 23 (2%) were Hispanic. Most clinical features at presentation were similar to non-Hispanic EoE patients but histologic response to tCS was numerically lower (38% vs 57%). Non-White EoE patients (13%) were younger at diagnosis and had less insurance, lower zip code-level income, shorter symptom duration, more vomiting, less dysphagia and food impaction, fewer typical endoscopic features, and less dilation. Of 475 patients with race data treated with tCS, non-Whites had a significantly lower histologic response rate (41% vs 59%; P = 0.01), and odds of histologic response remained lower after controlling for potential confounders (adjusted odds ratio 0.40, 95% confidence intervals: 0.19-0.87). DISCUSSION Few EoE patients at our center were Hispanic, and they had similar clinical presentations as non-Hispanics. The non-White EoE group was larger, and presentation was less dysphagia-specific. Non-White patients were also less than half as likely to respond to tCS.

中文翻译：

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少数族裔和种族嗜酸性粒细胞性食管炎患者的临床特征和对局部类固醇的治疗反应。

引言 不同种族的嗜酸性粒细胞性食管炎 (EoE) 表现和结果的差异仍有待研究。我们的目的是确定西班牙裔/拉丁裔或非白人种族的 EoE 患者在诊断时的表现或对局部皮质类固醇 (tCS) 治疗的反应是否存在差异。方法 这项回顾性队列研究包括新诊断出 EoE 并记录民族或种族的任何年龄的受试者。对于接受 tCS 治疗并进行后续内窥镜检查/活检的患者，我们评估了组织学反应（<15 个嗜酸性粒细胞/hpf）、整体症状反应和内窥镜反应。将西班牙裔 EoE 患者与非西班牙裔患者在基线以及治疗前后进行比较。对白人与非白人重复了相同的分析。结果 在 1,026 名有种族数据的 EoE 患者中，只有 23 名 (2%) 是西班牙裔。大多数临床特征与非西班牙裔 EoE 患者相似，但对 tCS 的组织学反应在数值上较低（38% 比 57%）。非白人 EoE 患者 (13%) 诊断时年龄较小，保险较少，邮政编码级别的收入较低，症状持续时间较短，呕吐较多，吞咽困难和食物嵌塞较少，典型内镜特征较少，扩张较少。在接受 tCS 治疗的 475 名种族数据患者中，非白人的组织学缓解率显着较低（41% vs 59%；P = 0.01），并且在控制潜在混杂因素后，组织学缓解的几率仍然较低（调整后的优势比 0.40， 95% 置信区间：0.19-0.87)。讨论 我们中心很少有 EoE 患者是西班牙裔，他们的临床表现与非西班牙裔相似。非白人 EoE 组人数较多，且吞咽困难的表现较少。非白人患者对 tCS 做出反应的可能性也不到一半。