Background Surgical stress and pain result in activation of hypothalamus-pituitary-adrenal axis. The aim of this study was to establish the effects of postoperative pain and various modalities of analgesic administration on salivary and serum cortisol levels, as well as to establish the validity of salivary cortisol as a stress indicator in surgical patients. Methods A randomized controlled trial involved 60 patients scheduled for elective abdominal aortic aneurysm surgery. Patients were randomly divided into two groups depending on the model of postoperative analgesia. The first group (MI - morphine intermittently) included patients given morphine doses 0.1 mg/kg/6h s.c. intermittently. The second group (MPCA - morphine patient-controlled analgesia) included patients who received morphine via the PCA system - intravenous administration of morphine adjusted to a dose of 1 mg per shot and a lockout interval of 6 minutes.

中文翻译：

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唾液皮质醇作为手术患者压力的生物标志物。

背景 手术应激和疼痛会导致下丘脑-垂体-肾上腺轴激活。本研究的目的是确定术后疼痛和各种镇痛给药方式对唾液和血清皮质醇水平的影响，以及确定唾液皮质醇作为手术患者应激指标的有效性。方法 一项随机对照试验涉及 60 名计划接受择期腹主动脉瘤手术的患者。根据术后镇痛模式将患者随机分为两组。第一组（MI - 间歇吗啡）包括间歇性皮下给予吗啡剂量 0.1 mg/kg/6h 的患者。第二组（MPCA——吗啡患者自控镇痛）包括通过 PCA 系统接受吗啡的患者——吗啡静脉注射调整为每次注射 1 毫克的剂量，锁定间隔为 6 分钟。