Background. Chronic obstructive pulmonary disease (COPD) remains one of the most prevalent pathologies in the world and is among the leading causes of mortality and morbidity, partially due to underdiagnosis. The use of clinical questionnaires to identify high-risk individuals to take them to further diagnostic procedures has emerged as a strategy to address this problem. Objective. To compare the performance of the COULD IT BE COPD, CDQ, COPD-PS, LFQ, and PUMA questionnaires for COPD diagnosis. Methods. A cross-sectional study was carried out on subjects who underwent spirometry in the third-level center. Data were collected between January 2015 and March 2020. Bivariate analysis was performed between the study variables and the presence of COPD. The area under the receiver operating characteristics curve (AUC-ROC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR−) for each questionnaire were calculated. The AUC-ROCs were compared with the DeLong test, considering a value <0.05 statistically significant. Results. 681 subjects met the inclusion criteria and were taken to the final analysis. The prevalence of COPD was 27.5% (187/681). The mean age of the subjects was 65.9 years (SD ± 11.79); 46.3% (315/681) were female, and 83.6% (569/681) reported respiratory symptoms. Statistically significant relationship was found for COPD diagnosis with male sex, older age, respiratory symptoms, and exposure to wood smoke ( value <0.05). The AUC-ROCs of the questionnaires were between 0.581 and 0.681. The COULD IT BE COPD questionnaire had a lower discriminatory capacity AUC-ROC of 0.581, concerning the other scores (DeLong test,  = 0.0002). Conclusion. The CDQ, COPD-PS, LFQ, PUMA, and COULD IT BE COPD questionnaires have acceptable performance for the diagnosis of COPD together with low sensitivity and specificity. Therefore, its use must be complemented with other diagnostic tests or techniques such as pulmonary function tests.

中文翻译：

---

五种慢性阻塞性肺疾病临床问卷诊断性能比较

背景。慢性阻塞性肺疾病（COPD）仍然是世界上最普遍的疾病之一，也是死亡率和发病率的主要原因之一，部分原因是诊断不足。使用临床问卷来识别高危个体，并带他们进行进一步的诊断程序已成为解决这一问题的策略。客观的。比较 COULD IT BE COPD、CDQ、COPD-PS、LFQ 和 PUMA 问卷在 COPD 诊断中的表现。方法。对在三级中心接受肺活量测定的受试者进行了横断面研究。数据收集于 2015 年 1 月至 2020 年 3 月期间。对研究变量和 COPD 的存在进行双变量分析。每份问卷的受试者工作特征曲线下面积 (AUC-ROC)、敏感性、特异性、阳性预测值 (PPV)、阴性预测值 (NPV)、阳性似然比 (LR+) 和阴性似然比 (LR−)被计算出来。将 AUC-ROC 与 DeLong 检验进行比较，考虑值 <0.05 有统计显着性。结果。681名受试者符合纳入标准并进入最终分析。COPD 的患病率为 27.5% (187/681)。受试者的平均年龄为 65.9 岁 (SD ± 11.79)；46.3% (315/681) 为女性，83.6% (569/681) 报告有呼吸道症状。发现 COPD 诊断与男性、年龄、呼吸道症状和木烟暴露存在统计学显着关系（值<0.05）。问卷的AUC-ROC在0.581和0.681之间。就其他分数而言，COULD IT BE COPD 问卷的辨别能力 AUC-ROC 较低，为 0.581（DeLong 检验 = 0.0002）。结论。CDQ、COPD-PS、LFQ、PUMA 和 COULD IT BE COPD 问卷对于 COPD 的诊断具有可接受的性能，但敏感性和特异性较低。因此，其使用必须辅之以其他诊断测试或技术，例如肺功能测试。