INTRODUCTION Skeletal growth arrest lines (GAL) are transverse lines of metaphyseal radiodensity accompanying episodic severe physiological stress. They are poorly described in fetal remains. MATERIALS AND METHODS We searched our autopsy practice for instances of fetal GAL in post mortem radiology, and correlated them with long bone histology and placental pathology. We describe the appearance, distribution, and pathology of GAL in a cohort of fetal autopsies, and compare the placental pathology accompanying GAL to the placental pathology of asymmetrical growth restriction (AGR) in the same time period. RESULTS In 2108 consecutive fetal post mortems, we found 20 cases with GAL. About 16 were in singletons with AGR. In these 16, the distribution of placental pathologies was similar to a contemporaneous cohort of 113 cases with AGR. Of the remaining 4, two twins out of 9 sets of monochorionic twins with AGR demonstrated GAL. One case of GAL had symmetrical growth restriction with cytomegalovirus infection, and one case had no AGR and an old, unexplained retroplacental hemorrhage. On histology, GAL are characterized by a region of mineralized chondroid, which is variably incorporated into irregular trabecular bone. DISCUSSION GALs accompany a variety of placental pathologies and twin-twin transfusion, suggesting episodic disease progression.

中文翻译：

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胎儿遗骸中的骨骼生长停滞线：组织病理学和相关胎盘病理学。

简介 骨骼生长停滞线 (GAL) 是伴随偶发性严重生理应激的干骺端放射密度横线。在胎儿遗骸中对它们的描述很少。材料和方法 我们在尸检实践中搜索了死后放射学中胎儿 GAL 的实例，并将其与长骨组织学和胎盘病理学相关联。我们描述了一组胎儿尸检中 GAL 的外观、分布和病理学，并将 GAL 伴随的胎盘病理学与同一时期的不对称生长受限 (AGR) 胎盘病理学进行比较。结果在连续2108例胎儿尸检中，发现20例患有GAL。大约 16 人处于 AGR 单身状态。在这 16 例中，胎盘病理的分布与同期 113 例 AGR 病例的分布相似。其余 4 例中，9 组具有 AGR 的单绒毛膜双胞胎中有两例表现出 GAL。1 例 GAL 患者出现对称性生长受限并伴有巨细胞病毒感染，1 例患者无 AGR，且有不明原因的陈旧性胎盘后出血。在组织学上，GAL 的特征是矿化软骨样区域，该区域不同程度地融入不规则骨小梁中。讨论 GAL 伴随着多种胎盘病变和双胎输血，表明疾病呈偶发性进展。