Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.,PLOS Genetics

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Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.
PLOS Genetics ( IF 4.5 ) Pub Date : 2023-09-25 , DOI: 10.1371/journal.pgen.1010901
Ana Catalán _{1,

2} , Justin Merondun ₂ , Ulrich Knief _{2,

3} , Jochen B W Wolf _{1,

2}

Affiliation

The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid autosomes (AA) and the hemizygous sex chromosome (X). Female heterogametic systems (AAf Zf, AAm ZZm) tend to only show partial dosage compensation (0.5 < Zf:AAf < 1) and dosage balance (0.5

中文翻译：

染色质可及性，而不是 5mC 甲基化协变，在乌鸦中具有部分剂量补偿。

遗传性别决定的进化常常伴随着限性染色体的退化。雄性异配系统已经进化出趋同的表观遗传机制，恢复了二倍体常染色体（AA）和半合子性染色体（X）之间基因剂量的不平衡。雌性异配系统（AAf Zf、AAm ZZm）往往仅表现出部分剂量补偿（0.5 < Zf:AAf < 1）和剂量平衡（0.5

更新日期：2023-09-25

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