Objective

To compare recovery times of sugammadex with spontaneous recovery from rocuronium-induced neuromuscular block (NMB) in dogs.

Study design

Retrospective, unmatchedcase-control study.

Animals

A total of 10 dogs administered sugammadex and 10 dogs recovering spontaneously from rocuronium-induced NMB.

Methods

Files of dogs administered rocuronium between March and August 2023 were inspected. The train-of-four (TOF) count at the time of sugammadex administration and the time between administration and TOF ratio >90% (recovery time) were recorded. The recovery time for those not administered reversal agents was considered from the first TOF value >0 until TOF ratio >90%. The dose of sugammadex and the cumulative dose of rocuronium were recorded. Rocuronium doses and recovery times were compared using Mann–Whitney tests. The coefficient of determination (R²) between the cumulative rocuronium dose and sugammadex dose and the recovery time were calculated.

Results

Dogs in the sugammadex and spontaneous recovery groups were administered intravenously (IV) 0.76 (0.4–2.6) and 0.61 (0.3–2.9) mg kg^–1 of rocuronium, respectively (p = 0.325). Recovery time after 3.9 (2.9–5.5) mg kg^–1 of sugammadex IV was 1 (1–3) minutes and was 20 (10–35) min for spontaneous recovery (p < 0.0001). The R² for rocuronium and sugammadex doses and recovery times were 0.19 (p = 0.2) and 0.012 (p = 0.758).

Conclusions and clinical relevance

Sugammadex 2.9–5.5 mg kg^–1 reversed moderate (TOF count 1–3) or deep (TOF count 0) rocuronium-induced NMB within 3 minutes, substantially faster than spontaneous recovery.

中文翻译：

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Sugammadex 在临床环境中逆转中度至深度罗库溴铵阻滞：10 只狗的回顾性报告

客观的

比较舒更葡糖的恢复时间与罗库溴铵诱导的犬神经肌肉阻滞 (NMB) 的自发恢复时间。

学习规划

回顾性、无与伦比的病例对照研究。

动物

共有 10 只狗服用了舒更葡糖，其中 10 只狗从罗库溴铵诱导的 NMB 中自然恢复。

方法

检查了 2023 年 3 月至 8 月期间服用罗库溴铵的狗的档案。记录舒更葡糖给药时的四连组 (TOF) 计数以及给药与 TOF 比率 >90% 之间的时间（恢复时间）。对于那些未施用逆转剂的患者，恢复时间被认为是从第一个 TOF 值 >0 到 TOF 比率 >90%。记录舒更葡糖的剂量和罗库溴铵的累积剂量。使用曼-惠特尼试验比较罗库溴铵剂量和恢复时间。计算累积罗库溴铵剂量和舒更葡糖剂量与恢复时间之间的决定系数(R ^{2 )。}

结果

舒更葡糖组和自然恢复组的狗分别静脉注射（IV）0.76（0.4-2.6）和0.61（0.3-2.9）mg kg ^-1罗库溴铵（p  = 0.325）。3.9 (2.9–5.5) mg kg ^–1舒更葡糖 IV 后的恢复时间为 1 (1–3) 分钟，自发恢复时间为 20 (10–35) 分钟 ( p < 0.0001)。罗库溴铵和舒更葡糖剂量和恢复时间的R ^{2分别为 0.19 (} p  = 0.2) 和 0.012 ( p  = 0.758)。

结论和临床相关性

Sugammadex 2.9–5.5 mg kg ^–1可在 3 分钟内逆转中度（TOF 计数 1–3）或深度（TOF 计数 0）罗库溴铵诱导的 NMB，明显快于自发恢复。