Objectives

The current research explores the anticancer effects of pH sensitive CVC-ZnO QDs (Carvacrol-loaded Zinc Oxide Quantum Dots) on DMBA induced mammary carcinoma in rats.

Methods

Female SD rats were used, and mammary cancer was induced by chemical carcinogen via subcutaneous injection near the mammary gland. Different concentrations of CVC-ZnO QDs were orally supplemented to evaluate the optimum dose. We assessed the growth rate, body weight changes, tumor volume, tumor incidence and tumor burden in both the inducer and treatment groups. We also evaluated the biochemical parameters (antioxidant status, lipid peroxidation, detoxification enzymes, and lipid profile) and histopathological changes in the kidney and mammary tissues.

Results

Our findings indicate that CVC-ZnO QDs treated rats significantly decreased the tumor weight, incidence, burden, lipid peroxidation levels, phase I detoxification enzyme activities and increased the body weight, phase II detoxification enzyme activities, and antioxidant status compared to the DMBA alone treated rats. CVC-ZnO QDs treatment also altered the lipid profile of plasma and mammary tissue. Furthermore, histopathological results confirmed that the CVC-ZnO QDs protect against DMBA-mediated damage to the mammary and kidney.

Conclusion

The findings indicate that the CVC-ZnO QDs administered at 4 mg/kg b.w exhibited a significant anticancer effect against DMBA-induced mammary cancer.

中文翻译：

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pH敏感香芹酚氧化锌量子点对DMBA诱导的雌性斯普拉格道利大鼠乳腺癌的抗癌作用

目标

目前的研究探讨了 pH 敏感的 CVC-ZnO QD（负载香芹酚的氧化锌量子点）对 DMBA 诱导的大鼠乳腺癌的抗癌作用。

方法

采用雌性SD大鼠，通过乳腺附近皮下注射化学致癌剂诱发乳腺癌。口服补充不同浓度的CVC-ZnO QDs以评估最佳剂量。我们评估了诱导组和治疗组的生长速度、体重变化、肿瘤体积、肿瘤发生率和肿瘤负荷。我们还评估了肾脏和乳腺组织的生化参数（抗氧化状态、脂质过氧化、解毒酶和脂质谱）以及组织病理学变化。

结果

我们的研究结果表明，与单独使用 DMBA 治疗相比，CVC-ZnO QD 治疗的大鼠显着降低了肿瘤重量、发病率、负荷、脂质过氧化水平、I 期解毒酶活性，并增加了体重、II 期解毒酶活性和抗氧化状态老鼠。CVC-ZnO QDs 治疗还改变了血浆和乳腺组织的脂质分布。此外，组织病理学结果证实，CVC-ZnO QD 可以防止 DMBA 介导的乳腺和肾脏损伤。

结论

研究结果表明，以 4 mg/kg 体重施用的 CVC-ZnO QD 对 DMBA 诱导的乳腺癌表现出显着的抗癌作用。