Purpose

To investigate the correlation between volume of carbon dioxide elimination (V̇CO₂) and end-tidal carbon dioxide (PETCO₂) with cardiac output (CO) in a swine pediatric acute respiratory distress syndrome (ARDS) model.

Methods

Respiratory and hemodynamic variables were collected from twenty-six mechanically ventilated juvenile pigs under general anesthesia before and after inducing ARDS, using oleic acid infusion.

Results

Prior to ARDS induction, mean (SD) CO, V̇CO₂, PETCO₂, and dead space to tidal volume ratio (V_d/V_t) were 4.16 (1.10) L/min, 103.69 (18.06) ml/min, 40.72 (3.88) mmHg and 0.25 (0.09) respectively. Partial correlation coefficients between average CO, V̇CO₂, and PETCO₂ were 0.44 (95% confidence interval: 0.18–0.69) and 0.50 (0.18–0.74), respectively. After ARDS induction, mean CO, V̇CO₂, PETCO₂, and V_d/V_t were 3.33 (0.97) L/min, 113.71 (22.97) ml/min, 50.17 (9.73) mmHg and 0.40 (0.08). Partial correlations between CO and V̇CO₂ was 0.01 (−0.31 to 0.37) and between CO and PETCO₂ was 0.35 (−0.002 to 0.65).

Conclusion

ARDS may limit the utility of volumetric capnography to monitor CO.

中文翻译：

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猪小儿急性呼吸窘迫综合征模型的间接心输出量评估

目的

目的 研究猪小儿急性呼吸窘迫综合征( ARDS) 模型中二氧化碳消除量 (V̇CO ₂ ) 和呼气末二氧化碳 (PETCO ₂ ) 与心输出量 (CO) 之间的相关性。

方法

使用油酸输注诱导 ARDS 之前和之后，在全身麻醉下收集 26 头机械通气幼猪的呼吸和血流动力学变量。

结果

ARDS 诱导前，平均 (SD) CO、V̇CO ₂、PETCO ₂和死腔与潮气量比 (V _d /V _t ) 分别为 4.16 (1.10) L/min、103.69 (18.06) ml/min、40.72 (分别为 3.88) 毫米汞柱和 0.25 (0.09)。_{平均CO、V̇CO 2}和PETCO ₂之间的偏相关系数分别为0.44（95%置信区间：0.18–0.69）和0.50（0.18–0.74）。ARDS诱导后，平均CO、V̇CO ₂、PETCO ₂和V _d /V _t分别为3.33 (0.97) L/min、113.71 (22.97) ml/min、50.17 (9.73) mmHg 和0.40 (0.08)。CO 和 V̇CO ₂之间的偏相关性为 0.01（-0.31 至 0.37），CO 和 PETCO ₂之间的偏相关性为 0.35（-0.002 至 0.65）。

结论

ARDS 可能会限制容积二氧化碳图监测 CO 的效用。