Background: The correlation between pre-operative serum pre-albumin and surgical site infection (SSI) has been the focus of many studies. However, existing literature presents conflicting evidence on this association. Therefore, this meta-analysis was conducted to determine the significance of low serum pre-albumin as a prognostic factor SSI, and to assess the potential utility of pre-albumin in predicting SSI. Methods: A comprehensive literature search and analysis was conducted in PubMed, Web of Science, Cochrane of Library, Scopus, Embase, and Google Scholar databases through August 2022 to identify studies reporting low pre-operative serum pre-albumin levels in patients undergoing surgery and their association with SSIs. The pooled risk estimates were shown in odds ratio with 95% confidence interval. The random effect model was used according to the test of heterogeneity among studies. Subgroup analyses and sensitivity analyses were performed to identify the possible sources of heterogeneity. This meta-analysis was prospectively registered in the PROSPERO database (number: CRD42022376167). Results: Nine studies involving 5,306 patients were eligible. The results demonstrated an association between low pre-operative serum pre-albumin levels and a higher probability of developing SSI (odds ratio [OR], 2.04; 95% confidence interval [CI], 1.28-3.26). Conclusions: Our findings suggest that low serum pre-albumin level may serve as an independent and valuable predictor of SSI. These results provide important insights for clinicians in identifying high-risk patients and implementing preventive measures.

中文翻译：

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术前低血清前白蛋白对术后受试者手术部位感染的影响：系统评价和荟萃分析。

背景：术前血清前白蛋白与手术部位感染（SSI）之间的相关性一直是许多研究的焦点。然而，现有文献对这种关联提出了相互矛盾的证据。因此，本荟萃分析旨在确定低血清前白蛋白作为 SSI 预后因素的重要性，并评估前白蛋白在预测 SSI 中的潜在效用。方法：截至 2022 年 8 月，我们在 PubMed、Web of Science、Cochrane of Library、Scopus、Embase 和 Google Scholar 数据库中进行了全面的文献检索和分析，以确定报告接受手术和治疗的患者术前血清前白蛋白水平较低的研究。他们与 SSI 的关系。汇总风险估计以优势比显示，置信区间为 95%。根据研究间异质性检验，采用随机效应模型。进行亚组分析和敏感性分析以确定异质性的可能来源。该荟萃分析前瞻性地在 PROSPERO 数据库中注册（编号：CRD42022376167）。结果：涉及 5,306 名患者的 9 项研究合格。结果表明，术前血清前白蛋白水平较低与发生 SSI 的较高概率之间存在关联（比值比 [OR]，2.04；95% 置信区间 [CI]，1.28-3.26）。结论：我们的研究结果表明，低血清前白蛋白水平可能作为 SSI 的独立且有价值的预测因子。这些结果为临床医生识别高危患者和实施预防措施提供了重要的见解。