INTRODUCTION Due to the cardiotoxicity of cancer treatment and traditional risk factors for cardiovascular disease (CVD) such as obesity, diabetes, dyslipidemia, and hypertension, cancer patients are at higher risk of developing CVD. However, limited research exists on the correlation between chronic kidney disease (CKD) and CVD risk in cancer patients. METHODS This cross-sectional study selected cancer patients aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) conducted from 2015 to 2020. Multivariable logistic regression was used to assess the association between CKD and CVD in cancer patients. Additionally, subgroup analyses were conducted to investigate the association among different groups of cancer patients. RESULTS We included 1700 adult cancer patients (52.53% were female). After multivariable adjustment for covariates including traditional CVD factors, CKD was significantly associated with CVD, with an odds ratio (95% confidence interval) and P-value of 1.61(1.18,2.19) and 0.004. Subgroup analyses after multivariable adjustment showed a significant correlation between CKD and increased CVD risk in the following populations: age ≥60 years, males, White ethnicity, and individuals with or without traditional CVD factors (obesity, diabetes, dyslipidemia, and hypertension). CONCLUSIONS CKD remains a significant factor in the higher risk of CVD among adult cancer patients in the United States, even after adjustment for traditional CVD risk factors. Therefore, to reduce the risk of CVD in cancer patients, it is important to treat CKD as a non-traditional risk factor for CVD and actively manage it.

中文翻译：

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癌症患者慢性肾病与心血管疾病的关联：一项横断面研究。

简介 由于癌症治疗的心脏毒性以及肥胖、糖尿病、血脂异常和高血压等心血管疾病 (CVD) 的传统危险因素，癌症患者发生 CVD 的风险较高。然而，关于癌症患者慢性肾脏病 (CKD) 与 CVD 风险之间的相关性的研究有限。方法这项横断面研究从2015年至2020年进行的国家健康和营养检查调查（NHANES）中选择了年龄≥20岁的癌症患者。使用多变量逻辑回归来评估癌症患者中CKD和CVD之间的关联。此外，还进行了亚组分析以调查不同癌症患者群体之间的关联。结果 我们纳入了 1700 名成年癌症患者（52.53% 是女性）。对包括传统 CVD 因素在内的协变量进行多变量调整后，CKD 与 CVD 显着相关，优势比（95% 置信区间）和 P 值为 1.61（1.18，2.19）和 0.004。多变量调整后的亚组分析显示，以下人群中 CKD 与 CVD 风险增加之间存在显着相关性：年龄≥60 岁、男性、白人以及有或没有传统 CVD 因素（肥胖、糖尿病、血脂异常和高血压）的个体。结论 即使在调整传统 CVD 危险因素后，CKD 仍然是美国成年癌症患者 CVD 风险较高的一个重要因素。因此，为了降低癌症患者CVD风险，将CKD作为CVD的非传统危险因素进行治疗并积极管理非常重要。